W: Craig Stammen (3-4) L: Will Harris (0-3)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | R | H | E | |
| D-backs | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 4 | 9 | 0 |
| Nationals | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 1 | 5 | 8 | 0 |
The Arizona Diamondbacks were not only beaten by a former third base coach in Matt Williams, former player Adam LaRoche hit the game winning solo home run to give the Washington Nationals the 5-4 win. The win was the Nationals seventh in a row and their third straight walk off win. The walk off loss is the third in less than a week for the D-backs.
The Diamonbacks squandered another stellar outing from Vidal Nuno, as he pitched seven innings while allowing just two earned runs on five hits, two walks and seven strikeouts. Both of the runs Nuno gave up came in the seventh inning, where Wilson Ramos hit a two run home run.
Jordan Zimmerman was very good for the Nationals as well, also throwing seven innings while allowing three runs on four hits and three walks. Didi Gregorious ruined Zimmerman's chances of earning a win with his own two run homer in the eighth. Washington did the same exact thing to Vidal Nuno in the bottom half, scoring two runs off Brad Ziegler. Anthony Rendon hit a RBI triple, all to be brought home on Jayson Werth's sacrifice fly.
David Peralta answered for the D-backs in the top of the ninth with his solo homer off Tyler Clippard.
The D-backs will seek redemption on Tuesday in game two of the four game series, sending the red hot Chase Anderson to the mound to take on Stephen Strasburg.