The New Orleans Saints lost 26-24 on a last second 29-yard field goal by Cleveland Browns kicker Billy Cundiff.
"It's frustrating because we expect to win," Saints quarterback Drew Brees said. "You can point to one play in each of these games. We're one play in each game from being 2-0 instead of 0-2. That hurts."
Even though Brees had a rough game compared to his high standards, he moved into fourth place on the National Football League's all-time career yardage list.
On Sunday, he entered the game needing 62 yards to pass Hall of Famer John Elway. He overtook the Broncos legend on a six-yard pass to tight end Jimmy Graham.
Brees had a rough first half before closing with a flourish. He and Graham combined for 57 yards, including nine on a TD pass with 3 seconds left that brought the Saints within 16-10.
The next milestone will take longer to achieve, as Brees trails No. 3 Dan Marino by nearly 10,000 yards.
The career leaders are: Brett Favre (71,838), Peyton Manning (65,233) and Dan Marino (61,361). Brees has a long way to go until he can move into third place.
The 38-year-old has passed for 51,414 yards, 364 touchdowns, and 178 interceptions in his 14-year career.