The Reds welcomed the pair back into the starting eleven on Sunday and they made a massive impact in their 6-0 thrashing of Aston Villa, with Sturridge opening the scoring and Coutinho setting up two goals.
With the two having been sidelined by niggling injuries in recent months, Jürgen Klopp only got his first glimpse of the pair on the pitch alongside the in-form Roberto Firmino at Villa Park.
And after the successful maiden debut of the Reds' fluid front-three, Clyne, speaking prior to their Europa League last 32 first-leg away at FC Augsburg, believes that provided Sturridge and Coutinho can stay fit - they can fire Liverpool to success in the final months of the campaign.
Clyne backs attacking duo to spur Liverpool on
The right-back declared that Sturridge and Coutinho "are both quality players" and said they are "massive" for the team because they can "get us goals and offer a real attacking threat."
With the Capital One Cup final against Manchester City to come later this month, Clyne added that it's "good to have them back" and explained: "You can see the difference their quality makes to us."
The England international said he is "sure" that the two are "hungry and fresh" for the rest of the season and lauded a "good all-round performance" away at Villa, saying that they "scored a lot of goals and were solid in defence."
The 24-year-old said that Liverpool were "clinical" in the West Midlands but insisted that's what they "have to be moving forward" because the side can get "even better in the future."
Clyne said that they "had a lot of injuries during a difficult period" and bemoaned the fact that the Reds "lost quality players at an important time" but declared that they "have got a lot of them back now" and are hoping to "push on for the rest of the season" and to "build up our momentum."
Reds aware of Augsburg threat, says full-back
The defender celebrated his first league goal in Liverpool colours at Villa and is likely to retain his spot in the back-four as Klopp's charges travel to Germany to take on Augsburg at the WWK Arena.
Clyne acknowledged that it "will be difficult" but insisted that they "want to get into the next round" and "keep winning" in order to try and "reach the final."
"It would be great if we could win that cup," declared the Reds No.2, who said that they "know it offers a route to the Champions League" next year and are "taking it seriously" as a means to qualify.