Philippe Coutinho, Danny Ward and Joe Allen were the Liverpool players involved in action as the March international break got underway.
Despite having been yet to make a single senior appearance for the Reds, after he was recalled from a loan spell at Aberdeen in January, Ward made his debut for Wales under the watchful eye of Chris Coleman.
Ward and Allen play as Wales draw
Coming on for experienced Premier League goalkeeper Wanye Hennessey at half-time against Northern Ireland, Ward managed 15 minutes without conceding a goal, before being unable to keep out a Craig Cathcart header.
It was clearly a game used by Coleman to experiment with some less familiar faces ahead of Euro 2016, which explains why Liverpool midfielder Joe Allen only made a 20 minute cameo appearance from the substitutes bench.
Allen was on the pitch when Wales equalised, Simon Church slotting home the penalty he won in the penultimate minute of normal time. The Red Dragons' next fixture is a friendly away to Ukraine on Monday.
Coutinho given 20 minutes for Brazil
A far more glamarous fixture took place in South America, with Brazil facing Uruguay in a World Cup qualifying match. Injury to Roberto Firmino restricted him from featuring, but Philippe Coutinho did, coming on for the last 20 minutes of the game.
All the excitement was over, in truth, by the time Coutinho was substituted on. Douglas Costa had given Brazil a first minute lead, doubled by Renato Augusto. Edinson Cavani pulled one back for Uruguay before Luis Suarez, a man known all too well by Liverpool, scored himself to ensure the match ended 2-2.
As far as Saturday night's action goes, there are four Liverpool players starting in the most high profile game of the night, between Germany and England. Emre Can starts for the home side, whilst Nathaniel Clyne, Jordan Henderson and Adam Lallana lineup for England.