Jürgen Klopp’s men currently sit in ninth place in the table, two points behind the Potters, but have two games in hand in order to jump above them in the standings.
Both clubs are searching for a European spot, but Liverpool’s focus may remain more on the Europa League, in hope of securing a Champions League place through winning the competition.
Some new faces will be brought into the starting eleven on Sunday, due to injuries and suspensions, as they hope to improve upon their position in the league.
Captain Jordan Henderson has been ruled out for the rest of the season after picking up a knee ligament injury during the midweek game in Dortmund.
The Reds will also be without fellow midfielder Emre Can, as he is suspended after picking up his 10th yellow card of the campaign last time out.
This paves the way for Joe Allen to start, with Lucas Leiva and Kevin Stewart making possible comebacks, after both returning from injury.
Stoke have been boosted with the return of two key players. Centre-back Ryan Shawcross will return to the Stoke side, along with Xherdan Shaqiri who have both overcome their injury problems.
However, Marko Arnautović is a doubt for the game, and first choice keeper Jack Butland will not play again this season after sustaining an injury on international duty.
The Potters have enjoyed a successful season so far under Mark Hughes, with the hope of European football next season still a possibility.
With Stoke breaking their transfer record earlier this season with an £18 million signing of Giannelli Imbula, they could be spending heavy in the summer to try and compete nearer the top.
They've finished ninth in the past two seasons, but could beat that club record this season in what has been a tumultuous term for all involved.
The two sides have already met three times this season, with the Reds winning twice 1-0, and then beating Stoke again on penalties after a 1-0 loss in the other game - a Capital One Cup semi-final second-leg.
The Potters' last league win at Liverpool was in 1959, with Liverpool winning 26 times since then.
The last four league games between the two sides have produced 17, averaging more than four a game.
Liverpool have only won three times at Anfield since Klopp took charge, drawing five times and losing twice.