A win for Jürgen Klopp’s men could see them rise to sixth in the table, whereas a win for Swansea City could see them climb four places into eleventh - dependent on results elsewhere.
The German manager is expected to name a much changed side, similar to the team that played Bournemouth a few weeks ago, meaning several senior players will be given the weekend off.
Several big name players are expected to be left out of the squad this Sunday, ahead of the second-leg of the Europa League semi-final against Villarreal next Thursday.
Philippe Coutinho was withdrawn from the first-leg at half-time due to an illness and is not expected to play any part.
Klopp has also hinted that back-up goalkeeper Danny Ward is set to start his second game for the club. He said: “Ward was really good against Bournemouth. It is likely that he will play at Swansea.”
Daniel Sturridge is also likely to start after being an unused substitute during the Europa League game.
The likes of Connor Randall, Martin Skrtel, Kevin Stewart, Christian Benteke, Jordon Ibe and Sheyi Ojo are all likely to feature be it from the start or off the bench.
Key Swansea men, forward Alberto Paloschi and midfielder Leroy Fer, will miss Sunday's game because of hamstring injuries.
This could pave the way for Jefferson Montero, Ki Sung-yueng and Bafetimbi Gomis to earn a recall into the starting eleven.
Swansea have had a tough season with the threat of relegation lurking over them towards the start and middle of the season.
This led to the sacking of Gary Monk and being replaced by Francesco Guidolin, who has done an impressive job since becoming manager.
The South Wales club are all but confirmed to be playing in the Premier League next season, but he has got key players like Gylfi Sigurðsson performing well again.
Liverpool are unbeaten in eight league and cup games against Swansea, winning the last five.
The Swans have won 1-0 in their last three matches at the Liberty Stadium.
Liverpool have scored 17 goals in their last six Premier League away games.