Liverpool are facing a huge battle to have both Adam Lallana and Georginio Wijnaldum fit for their home match against Manchester United next Monday night.
Both have injuries that are set to keep their availability for the clash unknown for a few days yet, as Jürgen Klopp is forced to consider potential alternatives for the game.
Midfielders sidelined either side of international duty
Lallana pulled out of Gareth Southgate's England squad after featuring in Liverpool's win away at Swansea City last weekend, having been forced off in the first half of that game with what looked like a groin injury.
He's been getting treatment on Merseyside ever since, and there were reports of him returning to training on Wednesday, but it remains touch and go as to whether or not he'll be fit to face the Reds' bitter rivals.
Wijnaldum's situation seems to be a little worse looking, after the Dutch midfielder went off during the second half of his country's game against France on Wednesday clutching his hamstring.
A typical hamstring injury would see a player out for around three weeks, with Wijnaldum set for a scan on Wednesday that will hopefully show that the injury isn't as worse as feared.
How could Liverpool line up?
However, it's likely that Klopp will be forced to reconsider his plans ahead of the game, changing some key elements of the side that have taken 16 points from their first seven Premier League games.
There's a possibilty that Philippe Coutinho could drop back into midfield for one of the injured players, with Sadio Mane, Roberto Firmino and Daniel Sturridge making up the rest of the front three.
Emre Can is extremely likely to come back into the side if both are injured, seeking his first league start after a spell on the sidelines himself, whilst Marko Grujic is something of a wildcard option for centre-midfield.