Dropping just two points in their last three matches, with recent signing Daley Blind to thank for his fundamental equaliser at the Hawthorns last week, Van Gaal will be aiming to devastate the 12-game unbeaten streak Mourinho can currently hold in high regard.
While the challenge is certainly no easy task, Chelsea’s midweek humiliation of the reigning Slovenian champions NK Maribor will provide a sense of buoyancy in the Manchester United camp, with limited attacking options taking its toll on the league leaders.
Definitive goal threats Diego Costa and Loïc Remy have both been ruled out of action by Mourinho, who has swiftly stated the duo will face a spell on the side lines through injury after their impressive 6-0 win in the Champions League fixture – with Remy scoring the first before being replaced by Didier Drogba just three minutes later.
Despit the fact Remy has expressed his hope to be in contention following his groin injury, it looks as if Drogba, who slotted home a penalty to secure their second goal of the night, will be a sure-fire starter, as the only remaining first team striker fully fit. André Schürrle is currently doubtful for the heated fixture through illness, but could return in time to face the Red Devils, and may be called upon for a spell in a central attacking position.
The Blues are set to be without Ramires in the middle, but should see Filipe Luis made his first start in the Premier League in his natural left-back position, as influential defender César Azpilicueta will miss out after seeing red against Crystal Palace last week.
Manchester United’s Wayne Rooney will similarly miss out, as the only certain absentee serving the final game of his three-match ban. Both Ander Herrera and Ángel Di María should be in contention, after being forced off last time out against West Bromwich Albion, and United fans could soon see a full strength midfield available for selection.
Within the midfield, Marouane Fellaini will be hopeful for a sporadic appearance, after coming off the bench to salvage his side’s hopes against the Baggies last Monday with an astonishing finish.
Antonio Valencia, Jonny Evans and Patrick McNair are all set to miss out, as Marcos Rojo may be selected in favour of a besieged Luke Shaw – allowing Chris Smalling to return in the middle, having watched from the bench as both Stephane Sessegnon and Saido Berahino broke through the defence.
A victory for the hosts could see them potentially rise to fourth place, while Chelsea will remain at the top of the table regardless of the result. Nevertheless, fans will hope to see the gap increased on Manchester City, who currently sit five points behind while facing a trip to fourth placed West Ham United. The visitors have enjoyed an unbeaten run against United that has now stretched across six matches, starting back in October 2012.
Both sides will be without crucial figures within their attacks, but include the squad depth to still promise an entertaining performance. United’s recent weaknesses at the back could be exploited down the wings by the likes of Eden Hazard and Willian, meaning they may opt for a central playing style with their restored midfield.
With the outcome crucial for both sides, neither manager will take the game lightly, and can be a chance for Mourinho to lay down another marker in the early hunt for the title, while Van Gaal can prove his worth within the United set-up.
Match Facts
There have been over 2.5 goals scored in 10 of Man Utd's last 11 home games in the Premier League.
Chelsea have won 8 of their last 9 matches in the Premier League.
Man Utd have been winning at both half time and full time in 6 of their last 8 home matches in the Premier League.
Chelsea have scored at least 2 goals in 8 of their last 9 matches in the Premier League.
Chelsea have been winning at both half time and full time in their last 3 matches in the Premier League.
Man Utd have won their last 3 home matches in the Premier League.