Starting off with a win
It hasn't exactly been a stellar pre-season campaign for the Hammers, but they have improved over the last few games, and will look to kick-off Olympic Stadium tenure on a high.
Many will be aware that Slaven Bilic's have already played at their new home, but it wasn't in friendly circumstance.
They headed into the second-leg of their Europa League play-off tie with NK Domzale, in need of a win after their 2-1 defeat in the first leg.
However a brace from Cheikhou Kouyate and another form Sofiane Feghouli gave them the perfect start with a 3-0 win, and will look to preserve their 100 percent record with a win over Massimiliano Allegri's side.
Playing against the best
Thursday's win saw the return of goalkeeper Darren Randolph, who showed his talents with the the Republic of Ireland this summer.
The keeper has recently been rewarded with a new four-year deal, and he shared his excitement with taking on the Italian giants.
He told whufc.com “It’s a team full of top European players and it’s a big game and another great occasion for us in front of another packed house."
He admitted: “I don’t know if I’ll be playing, as I was concentrating on Thursday’s game and just getting through [against NK Domzale]" but believes "we were back in training on Friday and will start looking forward to it."
Randolph concluded: “I think everyone looks forward to these last friendly matches when you play against the bigger teams" and admitted "it’s why everyone wants to play football, to play in these games against top players continuing on from the summer.”
Looking for more success
It has already been a successful summer for the Italians, as they look to have yet another successful season.
Their pre-season form has been decent so far, with a draw with Melbourne Victory and wins over Tottenham Hotspur and South China.
Those matches were part of their International Champions Cup commitments, and will see this match as a good preparation for their season opener against Fiorentina on August 20.
Bilic will still be without both Aaron Cresswell and Manuel Lanzini, who are still suffering from long-term injuries. Dimitri Payet returned to training on Saturday, but this game will come too early for the Euro 2016 hero.
However James Collins and Angelo Ogbonna could make a feature, after having a week of training under their belts.
West Ham United will take on Juventus in the Betway Cup at the Queen Elizabeth Olympic Park on Sunday, August 7 with kick-off at 1pm BST.