It's 14th against 15th at the Olympiastadion as both teams look to edge away from trouble.
The hosts have lost their last two games against Borussia Mönchengladbach and Bayern Munich, 3-2 and 0-1 respectively.
Dortmund will be looking to build on their 1-0 win at home to Hoffenheim last week. It has been a disappointing season so far for the visitors and they will be hoping to put a decent run together to get them back into the top half of the table.
In team news, Berlin boss Jos Luhukay has a few decisions to make. Jens Hegeler and John Heitinga could compete for a spot at centre-back. Ronny could get a chance in central attacking midfield, however Valentin Stocker is still out injured. Attacking duo Julian Schieber and Salomon Kalou both have a chance of starting up front.
For Dortmund, Jürgen Klopp confirmed goalkeeper Mitchell Langerak will be in the starting eleven until at least the winter break. Should Mats Hummels not be fit enough to start, Matthias Ginter will take his place in the side. Ilkay Gündogan will be looking to start in the number 10 role just behind the striker like last week where he scored the winner.
Both teams are in urgent need of improving their form. Berlin have lost four out of their last five Bundesliga games, while Dortmund have conceded two goals in every away match for the last six games in the league and have lost five of their last six on their travels.
Dortmund won the last fixture between the two teams and will be looking for a similar result this time.