The 80,000 fans in the Westfalenstadion on Saturday will be prepared for an emotional send-off for Jürgen Klopp as he takes charge for one last time at home.
It is also the last game of the Bundesliga season, with both teams level on 43 points and looking for a Europa League place. Augsburg occupy the last qualification space but should they lose to Borussia Mönchengladbach and Dortmund win, it will be Klopp's men who secure a spot in Europe next season. Dortmund could lose and still qualify for Europe, but they will have to beat VfL Wolfsburg in the DFB-Pokal final next week.
In team news, Dortmund will be hoping that Roman Weidenfeller will be fit to take his place in the goal this weekend while Mats Hummels should also return after missing the clash with Wolfsburg due to a foot injury. Marco Reus is also set to start to get more minutes under his belt in view of the DFB Cup final.
For the visitors, Clemens Fritz has been ruled out due to a foot injury while Davie Selke may also miss out on what would be his last game for the club prior to a switch to RB Leipzig in the summer, he has a groin strain.
Experienced midfielder Sebastian Kehl is also saying goodbye to the home crowd on Saturday as he prepares for retirement, and he should start alongside Ilkay Gundogan in the centre of midfield.
A winning finish to his spell at Signal Iduna Park is certain to be on Klopp's mind, but he will be desperate to leave the club with one final success in the cup competition before handing over to Thomas Tuchel, whose job to take Dortmund back to the Champions League looks to be a tough one.
Speaking ahead of the game, Klopp said: "Qualifying for the Europa League would mean everything. Absolutely everything. We've been playing in the Champions League for four years and now we can see what's changed in the Europa League."
Visiting head coach Viktor Skripnik is looking forward to the last game: "I hope that my team don't just want to take a look around the stadium, but that they will give everything to win this game. It's fantastic that we're at the focus of the attention in a 'final for Europe'. I'm delighted there's still something to play for."
Dortmund go into the game having won four out of their last six games in all competitions, while Bremen come into the game on the back of two wins in their last six.
During Klopp's reign, Dortmund have won two Bundesliga titles, one DFB-Pokal, two DFL-Supercups and finished runners-up to Bayern Munich in the 2013 Champions League final. Klopp will be hoping to make it two DFB-Pokal titles when they take on Wolfsburg next week in Berlin.
Possible line-ups:
Borussia Dortmund: Weidenfeller - Durm, Sokratis, Hummels, Schmelzer - Kehl, Gündogan - Mkhitaryan, Kagawa, Reus - Aubameyang
Werder Bremen: Casteels - Gebre Selassie, Prödl, Vestergaard, Sternberg - Bargfrede - Öztunali, Bartels - Junuzovic - di Santo, Selke