With Australia ranked second in the world, and Uruguay 19th, many are predicting one of the biggest mis-matches of the 2015 Rugby World Cup when the two sides face off on Sunday at the Villa Park.

The Wallabies started their campaign with a hard-fought 28-13 win over Fiji in Cardiff thanks to a pair of David Pocock tries, although the team did fail to pick up the bonus point which may be important.

For Uruguay, nothing is expected in terms of the result, but in their opener against Wales they put up more than a fight, in fact leading early on before succumbing to a 54-9 defeat. 

Cheika changes 14 after opening win

Scott Sio is the only man to keep his place in the starting XV, with the Wallabies giving their whole squad a run out in the opening two fixtures. Dean Mumm skippers the side from the second-row, where he will be partnered by man-mountain Will Skelton.

Quade Cooper slots in at fly-half, where he will orchestrate an exciting back-line which includes flyers Drew Mitchell, Henry Speight and Joe Tomane. Australia's tournament starts in earnest after this match, when they take on England and Wales, in matches that will determine the qualifiers from Pool A. 

South Americans alter ahead of huge test

After putting out a good performance against the Welsh, head coach Pablo Lemoine will be hoping for more of the same at Villa Park on Sunday.

Lemoine has changed five of his starters, which many of the alterations coming up front.

Front-row forwards Mateo Sanguinetti and German Kessler come into the side, with the 21-year-old Kessler last week becoming his country's youngest ever World Cup debutant. Also coming into the side are Franco Lamanna (lock), Juan De Freitas (flanker) and Leandro Leivas (winger). 

How the sides line up

Australia: 1. Scott Sio, 2. Tatafu Polota-Nau, 3. Toby Smith 
4. Dean Mumm (c), 5. Will Skelton 
6. Ben McCalman, 7. Sean McMahon, 8. Wycliff Palu 
9. Nick Phipps, 10. Quade Cooper 
11. Drew Mitchell, 12. Matt Toomua, 13. Henry Speight, 14. Joe Tomane, 15. Kurtley Beale
 
Replacements: 16. Stephen Moore, 17. Sekope Kepu, 18. Greg Holmes, 19. Kane Douglas, 20. Rob Simmons, 21. Will Genia, 22. Bernard Foley, 23. Tevita Kuridrani

Uruguay: 1. Mateo Sanguinetti, 2. German Kessler, 3. Mario Sagario
4. Santiago Vilaseca (c), 5. Franco Lamanna
6. Juan De Freitas, 7. Matias Beer, 8. Juan Manuel Gaminara
9. Agustin Ormaechea, 10. Felipe Berchesi
11. Rodrigo Silva, 12. Andres Vilaseca 13. Joaquin Prada, 14. Leandro Leivas, 15. Gaston Mieres

Replacements: 16. Nicolas Klappenbach, 17. Oscar Duran, 18. Carlos Arboleya, 19. Alejandro Nieto, 20. Diego Magno, 21. Fernando Bascou, 22. Alejo Duran, 23. Alberto Roman