Kyle Edmund claimed his second big scalp at the US Open as he toppled giant American John Isner to set up a last 16 clash with world number one Novak Djokovic.

Edmund, who is playing the main draw in New York for the first time in his career, recorded an incredible 6-4, 3-6, 6-2, 7-6 (7-5) victory over the 20th seed in two hours and 43 minutes on the Louis Armstrong court.

It is the first time the 21-year-old Brit has reached the fourth round of a major, meaning that he is now more than likely to top his career high ranking of world number 67.

"It's been a great tournament so far," said Edmund after the match: "Chances don't come very often against John. You have to capitalise when they do. You see how many aces he hits." He continued, "I played the big points well. I knew it would come down to one or two points. I'm just very pleased."

The Yorkshireman has now beaten two players ranked inside the world’s top 20 at this tournament, following his opening round victory over the 13th seed Richard Gasquet.

It should also be noted that the Frenchman’s game is a starkly different to that of Isner. While Gasquet usually excels in extended rallies from the back of the court, Isner’s ammunition comes from his skyscraper serve - which he fires down from his giant 6ft 10 frame. Yet Edmund has beaten them both.

Edmund relishing Djokovic battle

On playing Djokovic, the Brit added: "It's going to be a tough match. Playing the world number one is always going to be tough. He's rightfully world number one. He's been very consistent at a high level."

He concluded, "I'll learn from what happened in Miami (when Djokovic beat Edmund 6-3 6-3). Playing Isner at the French helped me tonight so maybe that will help me again."

That match in Paris earlier this year was the pair's only previous meeting, as Isner prevailed in straight sets.

Their second clash couldn’t have been more different, and it was Edmund who made the better start.

The perfect start

A loose service game from Isner in the fifth game of the match gave the Brit a decisive break, which he carried to take the opening set.

Once again Edmund dominated with his potent forehand and the Brit was quick to jump on anything which Isner dropped short in the court.

Edmund predictably triumphed from the baseline, however his first serve percentage dropped at the start of the second and Isner took his opportunity.

The Brit then saved two break points at the start of the third before breaking Isner’s serve for the second time in the following game.

Edmund holds his nerve

The Brit had to battle against a boisterous crowd, who rallied behind the American number one, however Edmund held his nerve and his serve throughout a dramatic fourth set.

A tie break was a fitting outcome and it was Edmund who dominated it, racing into a 6-3 lead.

Isner saved two match points with a couple of sledgehammer serves, however the Brit converted the third with a crushing forehand.

Djokovic will no doubt be the clear favourite going into the fourth round encounter, even so Serb is suffering from a lack of match practise after his third round opponent Mikhail Youznhy retired in the first set.

Britain will also have a representative in the last 16 of the women’s singles, after Johanna Konta swept past Switzerland’s Belinda Bencic with a 6-2 6-1 victory.

Konta will now take on Anastasija Sevastova from Latvia in round four.