New York is 0-3 following a 26-0 loss in Denver last week while Tennessee has won consecutive games against Seattle and Indianapolis after a season-opening defeat to Arizona.
The Titans will be thin at wide receiver as A.J. Brown and Julio Jones have both been ruled out with hamstring injuries. Defensively, outside linebacker Bud Dupree (knee), cornerbacks Caleb Farley (shoulder) and Kristian Fulton (ankle) and defensive lineman Larrell Murchison (shoulder) are all sidelined.
Tennessee's special teams unit will also take a hit as punter Brett Kern will miss out due to a right groin injury.
New York will also have issues at the wide receiver spot as Eijah Moore and Jeff Smith have concussions that will keep them out while Jamison Crowder is battling a hamstring injury and is questionable.
Also questionable for the Jets is tight end Tyler Kroft with a rib issue while running back La'Mical Perine has a non-COVID related illness. Defensively, safety Marcus Maye is set to miss out with an ankle injury.
Players to watch
Derrick Henry (Tennessee)
The best running back in football and the reigning Offensive Player of the Year is off to another strong start as he's rushed for 353 yards through the Titans' first three games to help lead the third-ranked rushing attack in the NFL.
Zach Wilson (New York Jets)
Picked second in the most recent NFL Draft, it's a rough start in the pros for the former BYU standout as he's been sacked 15 times and thrown seven interceptions through three games. Having thrown for 628 yards, Wilson at times has shown the arm strength and footwork that made him such a high draft choice.
The Titans and Jets haven't played since 2018 when Tennessee rallied from a nine-point deficit for a 26-22 victory, outscoring New York 13-0 in the fourth quarter.
Their last matchup at MetLife came in 2015 when Ryan Fitzpatrick threw for 263 yards and three touchdowns in a 30-8 rout, New York's third straight home win against Tennessee.
The game will be shown regionally on CBS with Greg Gumbel handling the play-by-play duties and Adam Archuleta as the analyst. Kick-off is set for 1pm.