Seattle sits atop the Western Conference standings with 13 points from their first five games while LAFC have only tallied five points through four games.
Goalkeeper Stefan Frei will be out of action after injuring his knee while midfielder Jordy Delem also exited the midweek win over San Jose with injury.
The duo join captain Nicolas Lodeiro (knee pain), Josh Atencio (quad strain) and Jimmy Madranda (hamstring strain) on the sidelines.
Seattle: Richey; O'Neill, Gomez, Tolo; A. Roldan, C. Roldan, Paulo, Rowe, Smith; Ruidiaz, Montero
LAFC: Sisniega; Palacios, Segura, Murillo, Blackmon; Atuesta, Blessing, Kaye; Baird, Rossi, Cifuentes
Ones to watch
Raul Ruidiaz has been one of the key players for the Sounders so far this season, having scored five goals while Rossi will be looked upon to carry the load for LAFC in the continued absence of Vela.
Having played less than a month ago, the two teams played to a 1-1 draw at Banc of California Stadium.
LAFC struck in the second minute courtesy of a Eduard Atuesta free kick. Seattle leveled through a Brad Smith 54th-minute header.
How to watch
The match will be televised by Fox Sports 1 with kickoff scheduled for 9:30 Eastern time.