NYCFC can clinch a playoff spot if they avoid defeat and one of several other teams lose while Miami can be eliminated if they lose or draw this match.
The Herons are missing Ryan Shawcross, Joevin Jones, Kieran Gibbs and Victor Ulloa through injury.
NYCFC will again be without Anton Tinnerholm, who is recovering from an Achilles injury. Nicolas Acevedo, Gudmundur Thorarinsson and Ismael Tajouri-Shradi are all sidelined with lower body issues.
Inter Miami: Marsman; Makoun, Pirez, Figal; Morgan, Matuidi, Gregore, Leerdam; Robinson, Higuain, Pizarro
NYCFC: Johnson; Amundsen, Chanot, Callens, Gray; Parks, Sands; Medina, Moralez, Thiago; Castellanos
Federico Higuain (Inter Miami)
Acquired by the club on October 20th, 2020, the Argentine has scored three times and contributed four assists in 28 appearances. He played alongside his brother Gonzalo, becoming the 18th pair of brothers to appear in an MLS match together.
They were the first brothers to score in the same match in April and after announcing his retirement on Friday effective at the end of the season, he brings to a close a long and stellar career.
Valentin Castellanos (NYCFC)
During the Boys In Blue's two-match homestand against D.C. and Chicago, he showed why he was the club's most important player, scoring three times and bringing his total to 16 on the season, tied for second in the league.
This is the second meeting of the season between the two sides with NYCFC claiming a 2-0 victory in August.
Castellanos opened the scoring in the 20th minute and added a penalty in first-half stoppage time.
The match will be streamed nationally on ESPN+. TUDN and Univison will carry the match on television while both teams will provide free audio coverage with more information on the respective club websites.
Kickoff is set for 1:30pm Eastern time.