The expansion side are coming off of a 2-0 defeat to Philadelphia, which saw their two-match winning streak snapped.
Atlanta posted their first clean sheet of the season in a victory over D.C. United and sit fourth in the Eastern Conference.
Forward Vinicus Mello had surgery on his left foot and will be sidelined for the foreseeable future. Midfielder Chris Hegardt joins him on the sidelines with a knee injury.
The Red and Black are without star man Josef Martinez, who is expected to undergo arthroscopic knee surgery and miss six to eight weeks.
Osvaldo Alonso is lost for the season after the midfielder tore his ACL. Luiz Araujo also looks to be out through a hamstring injury picked up earlier in the season.
Charlotte FC: Kahlina; Walkes, Fuchs, Corujo; Mora, Ruiz, Bronico, Lindsey; Bender, Swiderski, Alcívar
Atlanta United: Guzan; Gutman, Robinson, Franco; Hernández, Alonso, Wolff, Rossetto; Moreno, Martínez, Lennon
Ones to watch
Karol Swiderski (Charlotte FC)
Although they were shut out in Philadelphia last week, the Pole continues to impress in his debut season in MLS. As the club's designated player, he has four goals in his last three matches.
Swiderski is also capable of scoring anywhere on the pitch as evidenced by two of his goals coming from outside of the penalty area.
Brooks Lennon (Atlanta United)
The rock-solid fullback leads the Red and Black with 13 key passes and his wide, attacking runs allo for crosses to be delivered into the box, opening up opportunities for his teammates.
He's also Atlanta's primary corner kick-taker, which gives him the chance to create even more chances.
In their only previous meeting, Atlanta came away with a thrilling 2-1 victory at home.
On the hour mark, Lennon drew a foul in the penalty area and Martinez stepped up to convert the free-kick for his first goal of the season.
Charlotte leveled through substitute Adam Armour. After the Red and Black were caught out on a corner, the defender headed past Brad Guzan for the first goal in club history.
The match appeared headed for a draw until substitute Jake Mulraney beat his defender to fire home an unstoppable left-footed strike deep into second-half stoppage time.
The match will be televised nationally on ABC. Kickoff is set for 1:30pm Eastern time.