New York is unbeaten in four across all competitions, having won in Chicago last week to become the second team in MLS history to claim victory in their first five road matches of the season.
The Timbers are on a three-match winless run and have not scored in 282 minutes since they defeated the Vancouver Whitecaps almost a month ago.
Caden Clark remains out with a knee injury. Serge Ngoma, the 16-year-old top prospect for the club, will also miss out after tweaking his hamstring.
Defender Andres Reyes continues rehabilitation after having surgery on his fractured foot.
Felipe Mora continues to be sidelined as he continues recovery from knee surgery.
Diego Gutierrez (foot), Sebastian Blanco (thigh), Diego Chara (hip) and George Fochive (hip) all join Mora in missing this match.
Portland signed forward Nathan Fogaca from Brazilian side Coritiba for the rest of the season and with options on the following two campaigns.
New York Red Bulls: Coronel; Tolkin, Nealis, Long, Edwards; Morgan, Casseres Jr., Amaya, Luquinhas; Fletcher, Fernandez
Portland Timbers: Ivacic; Rasmussen, Tuiloma, Mabiala, Bonilla; Paredes, Williamson; Loría, Chara, Asprilla; Niezgoda
Ones to watch
Luquinhas (New York Red Bulls)
The Brazilian has been involved in a goal in each of New York's last three games and has proven to be a welcome addition in midfield with his playmaking abilities.
Yimmi Chara (Portland Timbers)
In what has been a disappointing start to the season, the Colombian has been a steady presence in the Portland side as he is only one of two players to appear in every match so far.
This is the first matchup between New York and Portland since 2019, won by the Red Bulls 2-0.
Kyle Duncan scored his first MLS goal as he ran onto a Josh Sims cross and beat then Timbers goalkeeper Steve Clark with a one-time shot just six minutes into the game.
The fullback then helped set up the visitors' second in the sixth minute of second-half stoppage time, intercepting a ball in the defensive third, passing to Marc Rzatkowski, who drew a foul from Jorge Moreira.
Daniel Royer stepped up to the spot and beat Clark to help snap New York's three-match losing streak.
The match will be streamed nationally on ESPN+. In New York, the MSG Network will have all of the coverage. FOX 12 Plus will televise all of the action in Portland.
Kickoff is set for 7pm Eastern time.