While New York has gone unbeaten on the road so far, they have only managed two draws out of five matches in Harrison.
Chicago has gone winless in seven, having finished two of those matches with ten men or less and have failed to score in four, finding the back of the net just three times in that span.
Spencer Richey (head) and Javier Casas Jr. (pelvis) have been ruled out of this match.
New York Red Bulls: Coronel; Edwards, S. Nealis, D. Nealis; Tolkin, Amaya, Luquinhas, Yearwood, Fernandez; Barlow, Klimala
Chicago Fire: Slonina; Bornstein, Ormsberg, Czichos, Sekulic; Mueller, Giménez, Navarro, Herbers; Shaqiri, Offer
Ones to watch
Xherdan Shaqiri (Chicago Fire)
He was the premier signing in the past MLS offseason, having scored 78 goals in 429 appearances across Europe. He's scored twice, both from the penalty spot, but while he doesn't have any goals from open play, he has had opportunities, registering 14 total scoring attempts and a team-leading 23 total attacking assists.
Patryk Klimala (New York Red Bulls)
He scored both goals last time these teams met and just played 45 minutes after returning from the league's health and safety protocols and with New York rotating strikers, a return to form would be welcome news for both the Pole and his club.
In April, the Red Bulls came from behind to grab a 2-1 victory at Soldier Field to become the second team in MLS history to win their first five matches on the road.
After an 80-minute weather delay and just a three-minute halftime break, New York leveled with quarter of an hour to play as Luquinhas found Patryk Klimala, who finished past Gabriel Slonina.
Four minutes later, the visitors went up a man as Jhon Duran was shown a second yellow card and three minutes after that, Czichos was sent off, giving the Red Bulls a two-man advantage.
Klimala was fouled in the box at the end of the match and the Pole stepped up and took the spot kick himself, converting to give New York all three points.
Kickoff is set for 7:30pm Eastern time.