Tiafoe had a four-set victory over countryman Christopher Eubanks in the first round followed by an easy win over Guido Pella in round two and capped off his first week with a dramatic five-set marathon triumph over fifth seed Andrey Rublev that lasted until 2:14am.
Auger-Aliassime won three tiebreakers over Russian qualifier Evgeny Donskoy in a four-set victory, followed with a straight sets win over Bernabe Zapata Miralles and outlasted 18th seed Roberto Bautista Agut in five sets in the third round.
This is the first career meeting between Tiafoe and Auger-Aliassime with the winner facing either German qualifier Peter Gojowczyk or Spanish sensation Carlos Alcaraz in the quarterfinals. This will be the first match of the night session on Arthur Ashe Stadium.
Power will be the name of the game when these two take the court. Tiafoe has a monster serve and forehand and will look to use those weapons at every opportunity. While he isn't totally uncomfortable in long rallies, he'll want to shorten the points as much as possible.
Auger-Aliassime is comfortable on all areas of the court and can hit winners off of both wings. He also plays an aggressive style, but can win the majority of long points and will look to test Tiafoe's patience as much as he can.
One area of Tiafoe's game that has greatly improved is at the net where he was both efficient and electric against Rublev and his willingness to develop and use another facet of his game to shorten points is nice to see.
This will be fun. Both players bring a lot of energy and excitement to the court. The biggest factor could be a wide-open draw where the winner is favored against either Gojowczyk or Alcaraz, so there is that added pressure.
If Tiafoe starts out well, the crowd will very much get behind him. Couple that with Auger-Aliassime's recent track record of losing big matches at majors (the Australian Open quarterfinal against Karatsev and Wimbledon quarterfinal against Matteo Berrettini) and you have the makings of another upset.
Prediction: Frances Tiafoe in four sets