The three-match series should reveal a lot about the depth England possess, and with a tour to India to follow, as well as a Champions Trophy on home soil in 2017, it is the perfect opportunity for players to put their hands up.
For Bangladesh, outside of their Asian neighbours, the Tigers very rarely are able to host one of the top-tier nations, and they have an opportunity themselves to claim a prized scalp.
There are plenty of things to look out for during the one-day series, and we have picked out five which could determine the eventual winners.
1. Is Ben Duckett ready for the big time?
Having taken county cricket by storm in 2016, Ben Duckett has secured his first international call-up and looks set to bat at three for England in Bangladesh.
The Northamptonshire batsman caught the selectors attention with some huge scores during the England Lions series victory this summer, as well as being an integral part in his county's T20 Blast success.
With Joe Root rested, and Alex Hales and Eoin Morgan making themselves unavailable due to security fears, Duckett has the opportunity to capitalise.
Capable of finding he boundary at will, it will be fascinating to see how fluent Duckett is against an international bowling attack. If the past two year's is anything to go by, the newby will have been given the blessings of his coaches to play his natural game, and that could be a sight to behold if he gets going.
2. Do Bangladesh have the requisite batting power?
From star opener Tamim Iqbal, down to Mahmuduallah who is expected to bat in the middle-order, Bangladesh have a number of batsmen capable of making England pay.
Tamim has been a known quantity for a good while now, and a lot of Bangladesh's hopes will rest on his shoulders. Capable of getting his team off to a flying start, the left-hander has shown a modicum of restraint over the last 12 months and his performances have improved because of it. Scores of 118 and 80 in the recent 2-1 series victory over Afghanistan prove that he is in good form and England will go a long way towards winning if they can see him off with the new ball.
Imrul Kayes made 121 against the England attack just three days before the series so it would not be a surprise to see him selected, while the trio of Mushfiqur Rahim, Shakib Al Hasan and Mahmudullah have all been there and done it on the international stage.
You then have the wildcard in Sabbir Rahman, who has been utilised at a number of positions in the batting lineup. He has shown at times that he potentially has the talent to become a big name in world cricket, but he has yet to show the consistency that is needed to do so. A big hitter who will target the spinners, Sabbir now has a 50-over and T20 World Cup under his belt, and should see this series as a chance to make the world take notice.
3. How does England's bowling attack cope in unfamiliar conditions?
Although it was only a warm-up game, England's first-choice bowling attack out in Bangladesh conceded more than 300 against a BCB Select XI on Tuesday.
Moeen Ali and Adil Rashid will resume spin duties and will be vital cogs in the bowling attack, probably expected to share 20 overs in Dhaka and Chittagong. Questions still remain over the competency of the spin duo, which will be highlighted in Bangladesh against players who enjoy facing spin.
Mark Wood has pulled out of the tour through injury, but there is a recall for the fit again Steven Finn, who will compete with the Yorkshire duo of Liam Plunkett and David Willey, as well as Chris Woakes and Jake Ball for what looks like three fast bowler spots.
Ben Stokes came through eight overs in Fathullah on Tuesday and was the most economical bowler, and his ability to bowl a couple of spells will really help to balance the England lineup.
4. Is Taskin Ahmed a superstar in the making?
Having made his international debut in 2014 two days shy of his 19th birthday, Taskin Ahmed has already been through a lot.
30 international matches later, and he has already had his bowling action scrutinised to the point where he was forced to miss the second half of the 2016 World T20 to have his action cleared by the ICC.
Now back playing for the Tigers, Taskin was the leading wicket-taker during Bangladesh's 2-1 series win over Afghanistan and his ability at the death could be crucial against a long England batting lineup stacked with big hitters.
A tall, fast bowler, Taskin has fond memories of Dhaka, having taken a career-best 5-28 against India on the ground back in 2014 on his ODI debut which earmarked him as a talent to watch out for.
5. How does Jos Buttler deal with the weight of captaincy on his shoulders?
The first name on the teamsheet in white-ball cricket, Jos Buttler will step up in the absence of Morgan to captain England during the three-match series.
As well as keeping wicket, the England hierarchy are putting a lot on Buttler's shoulders, and it will be fascinating to see how he copes.
Over the years we have seen some international cricketers crumble when given the captaincy, while others have flourished, and with it likely only an interim position Buttler should be able to handle the pressure.
He started well in the warm-up game, hitting a match-winning 80 not out from 64 deliveries, and England will likely need him at his swashbuckling best to come away with a series win.