In previous years, this fixture has produced some memorable moments and scorelines. But with Jurgen Klopp's men in such fantastic form, it's fair to say Steve McClaren would be happy with a point even before the game had kicked off.
How are both teams doing?
Klopp has got Liverpool firing again and they look quite the outfit. They have won four games on the bounce, scoring 13 in that time. Since the former-Borussia Dortmund man has taken over, they have beaten the likes of Chelsea, Manchester City and Southampton away from home.
Newcastle United, however, can't find any form. Their recent defeat to Crystal Palace means they now lie 19th in the table. They have conceded 30 goals in 14 games and have the worst goal difference in the division. Newcastle have failed to score in seven of their games, which is more than any other team in the top flight.
Liverpool - Newcastle has seen 132 goals in 41 games and is the highest scoring fixture in Premier League history involving a team that has not played in the top division every year since it began.
The Kop love Klopp
If Wednesday nights Capital One Cup tie was anything to go by, Newcastle should be worried. A second string Liverpool side dismantled Southampton by 6-1 and added further weight to the argument that Klopp is a tactical and managerial genius.
The way he has transformed Liverpool's underachieving group of players is phenomenal. Brendan Rodgers was all about tactical styles and the importance of systems, and even though Klopp has changed they way Liverpool play, his warm, friendly and unorthodox way of man-managing players is proving to be key.
With Daniel Sturridge back amongst the goals too, Liverpool look like a strong outfit again.
McClaren Misery
In contrast, the Magpies are in big trouble. McClaren seems to have lost the dressing room and the ability to coach players full stop. Another woeful drubbing last weekend will give fans very little hope that the men in black and white will be able to stop this rampant Liverpool side.
Fabricio Coloccini is a player who has came under intense scrutiny recently. Luckily for the Argentine, Mike Williamson returned from his loan speel at Wolverhampton Wanderers but has been ruled out, after tweaking his hamstring.
With many fans calling for his head, a thrashing on Sunday may finally lead to the sacking of McClaren. David Moyes has this week claimed he would welcome a return to the English game if the 'right opportunity' arrived.