Newcastle United have made two changes from last Sunday's 1-1 draw at Crystal Palace, with the goalkeeper coming in for his debut following his deadline day move.
The other move comes in Florian Lejeune in place of Ciaran Clark who picked up an injury at Selhurst Park. However, there is still no place for new striker Islam Slimani, who remains injured.
José Mourinho has made four changes to his from last Saturday's 2-0 win over Huddersfield Town, with the big inclusion being the return of Paul Pogba.
The club's most-expensive signing was dropped to the bench last week in place of Scott Mctominay, following a disagreement with Mourinho during the midweek defeat to Tottenham Hotspur.
Pogba comes in place of McTominay while Phil Jones, Ashley Young and Anthony Martial come in for Juan Mata, Luke Shaw, and Marcos Rojo
Newest star signing Alexis Sánchez maintains his position in the side, having opened his account last week with his strike against David Wanger's men.
Newcastle United starting XI: Dubravka, Dummett, Lascelles, Lejeune, Yedlin, Shelvey, Kenedy, Diame, Perez, Ritchie, Gayle.
Manchester United starting XI: De Gea, Valencia, Jones, Smalling, Young, Matic, Pogba, Lingard, Martial, Sanchez, Lukaku.
Newcastle United substitutes: Darlow, Murphy, Hayden, Manquillo, Joselu, Merino, Atsu.
Manchester United substitutes: Romero, Lindelof, Rojo, Mata, Carrick, Shaw, McTominay.