This year marks 10 years since Spurs last won a major trophy and a trip to Spotland provides them with a real chance of progressing to the quarter-finals.
However, the Dale are on the brink of their best ever FA Cup run as they have never progressed further than the last 16.
From Turin on Tuesday to a resurfaced Crown Oil Arena, Spurs may be without main man Harry Kane who is reportedly suffering from a twisted ankle.
The talk of the last round was the state of the Spotland pitch. Following some poor weather in the area, the pitch became nothing short of a swamp.
The Dale have suffered heavily as league games were cancelled due to the pitch being unfit to play on, leaving them with four games in hand on their relegation rivals.
Criticism from Tottenham boss Mauricio Pochettino was heard loud and clear as a new pitch was quickly laid in time for the Lilywhite's arrival.
Since the new pitch has been laid, Pochettino has taken the opportunity to apologise. The Spurs boss said: "First of all, I want to apologise to the people in Rochdale and the chairman and the people who took my comment the wrong way.
"My comment was about the care, first of all for the Rochdale players, our players and the competition that all of England watches on TV."
What can Spurs expect?
The Dale currently sit rock bottom of League One and are 11 points from safety, staring relegation in the face with a shortage of goals being their main issue.
Ian Henderson spearheads the Rochdale attack and was the hero in their replay match against Millwall where his goal saw the Dale through.
However, the 33-year-old has only managed to score eight goals in the league this season.
In midfield, Callum Camps provides the Dale with their main creative spark. Although he has not scored on a regular basis he could provide a threat going forward for the League One side.
Youngster Ryan Delaney has impressed in defence since his move from Burton Albion to Spotland in January where he has tightened up the backline in recent weeks.
Kane set to sit out
The Spurs striker has been up there with the world's most potent in front of goal this season having netted three already in the FA Cup so far.
Although Kane will be a huge miss for Spurs it will give them a different approach to the game with Fernando Llorente up top and Heung-Min Son playing off of him.
Lucas Moura has been tipped to make his full Spurs debut against Rochdale.
Lucas did make a brief appearance against Juventus on Tuesday where he showed the offensive threat he has to offer.
Tottenham: Vorm, Trippier, Foyth, Alderweireld, Rose; Wanyama, Winks; Son, Sissoko, Lucas; Llorente.