Spurs travel to Eindhoven for round three of the Champions League group stages.
Awaiting them will be PSV who currently top the Eredivisie but like Spurs sit bottom of the Champions League group on zero points.
Mauricio Pochettino's side are yet to return to their best this season but still remain winning in the league sitting just two points behind the leaders.
Huge game for both sides
With both sides without a point in the Champions League this seems a must-win game for both.
Spurs will feel they must take all six points in the two upcoming games against PSV to have any hope of progressing from the group.
However, PSV will be not turnover for Spurs as current leaders and reigning champions of the Eredivisie.
The Lilywhites tasted late defeat in their opening game away to Inter Milan after conceding two last-gasp goals from the hosts.
Much like the Londoners, PSV conceded their one-goal advantage to Inter who came from behind again to win 2-1.
Tottenham's Dele Alli is expected to return to training this week following his injury picked up before the international break.
However, he is not expected to travel to Eindhoven which was deemed too early in the midfielder's return to fitness.
Better news for Spurs fans as Christian Eriksen and Mousa Dembele are expected to start following their return to the team on Saturday's win at West Ham.
The two midfielders came on late in the game but were not started possibly with Wednesday's game in mind.
Mark van Bommel has all but a full strength side to choose from with his only absentee being Ryan Thomas who is sidelined due to a knee injury.
Van Bommel full of praise
The PSV boss was full of praise for Pochettino and his Spurs side ahead of the game.
He told the media Pochettino is one of his favourite managers in the current game:
"I admire him, to be able to stay with Spurs at the top in England for many years is a great achievement," the Dutchman said.
"He’s doing really well, it’s not normal to be so long at a top club," said the PSV boss. "He’s doing a really good job. He did a good job at Southampton before."
"Spurs have a lot of quality players and weapons to win games but we have that also. I don’t expect a high scoring game," the 41-year-old added.