Who will take his place is yet to be seen it may be a straight swap with Anthony Knockaert.
Or if The Seagulls want to go even more attacking they may shift Solly March over to the right wing and give Florin Andone his full Premier League debut either in the number ten role or upfront with Murray.
Cardiff will have to mark him tightly, in order to stop him doing any damage.
The 35-year-old striker has scored winning goals in two of Brighton's four wins so far this season.
Both Murphy and Reid combined have scored three goals between them meaning they have scored a third of the goals that Cardiff have scored this season in the Premier League.