Mignolet, Camacho, Fabinho, Lovren, Moreno, Milner, Keita, Jones, Shaqiri, Sturridge, Origi
Subs: Kelleher, Firmino, Mane, Salah, Hoever, Christie-Davies, Alexander-Arnold
Ruddy, Boly, Coady (C), Bennett, Jonny, Vinagre, Dendocker, Neves, Moutinho, Jota, Jimenez
Subs: Norris, Doherty, Cavaleiro, Costa, Gibbs-White, Saiss, Traore
Midfielder, Roman Saiss is also in the pipeline to return after overcoming a recent knee problem.
Liverpool are without long term absentees Joel Matip and Joe Gomez.
Klopp is expected to make a number of changes to his side, with Simon Mignolet and Alberto Moreno confirmed starters after a sporadic season on the sidelines behind Allison and Andrew Robertson.
Despite a valiant effort from Nuno's side, a goal either side of half time through Virgil Van Djik and Mohamed Salah gave Liverpool an important win in their hunt for the Premier League title.
The home side were knocked out at the first hurdle last year after losing a third-round replay to Swansea City 2-1, after the initial game finished 0-0.
The visitors managed to go one step further than tonight's opponents, however didn't make it any further after they were beaten 3-2 by West Bromwich Albion at Anfield in a game full of VAR controversy.
Liverpool's defeat in their last outing was their first in the league this season, and their first in all competitions for nine games.