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Spurs, meanwhile, climb to fifth and are four points off the Champions League places. Is this a springboard for a late charge?
FT thoughts
Bergwijn is a hugely exciting young talent and his fantastic goal could prove to be the start of a glittering career at Spurs.
For City, the complexion of the season doesn't significantly change. It's all about the Champions League.
But something just wasn't right. They faltered at the key moments, and they couldn't dig deep after going down to ten. Questions will rightfully be asked about the character of a side that looked unstoppable not so long ago.
Full time
There'll be five added minutes.
But, as it is, time is running out. Lloris makes an important catch as Fernandinho clips a ball into the box.
But now both sides are making their final alterations.
Off go Sterling and Lucas, on come Dier and Bernardo. An indication of the differing approaches for these last 10 minutes or so.
GOOOALLL! SPURS SCORE AGAIN!
Ndombele replaces Alli in a concurrent switch.
They win a corner as the Spurs fans demand they put the ball out so Bergwijn, who went to ground clutching his leg after giving chase, can be treated.
63' GOOOAALLL! BERGWIJN ON HIS DEBUT!
Zinchenko can have no complaints about the decision.
What an opportunity for Spurs now. They've not even had a shot in anger but might they now be the favourites?
RED CARD!
An awful miss!
Tanguy Ndombele, who's among the substitutes, could give Spurs a greater presence in midfield.
HT thoughts
Aguero, for his part, has had two glorious opportunities to open the scoring. And City have been asking all the questions.
The ground came alive after that VAR melee. Can Spurs harness the atmosphere as they look to put the visitors under real pressure in the second half?
They've only been able to produce flashes so far, but they've been handed a lifeline.
Half-time
What a miss!
PENALTY SAVED! BUT...
ANOTHER VAR REVIEW.
NO PENALTY THIS TIME. INCREDIBLE.
PENALTY to City
VAR awards the penalty!
Sterling had seen a close-range effort blocked in the frantic scenes which preceded it.
Aguero hits the post
Best chance so far.
They have edged the first quarter of the match, but Spurs will still be reasonably satisfied.
It looks a little nasty in slow-motion.
VAR briefly reviews Mike Dean's decision, considering whether to upgrade it to a red card. They choose to back the referee.
Alli has hobbled back to his feet.
Mike Dean wasn't interested.
Kick-off
Spurs: Lloris; Aurier, Alderweireld, Sanchez, Tanganga; Lo Celso, Winks; Bergwijn, Alli, Son.
City: Ederson, Walker, Fernandinho, Otamendi, Zinchenko; Rodri, De Bruyne, Gundogan; Mahrez, Aguero, Sterling.
Will City be boosted by Laporte's return? Will Bergwijn be thrown straight in at the deep end?
The day's other Premier League game
Victory would move the Gunners into the top half, but defeat would see them rather embarrassingly leapfrogged by their opponents.
You can follow that game LIVE, before joining us, by clicking here.
City team news
Aymeric Laporte and Fernandinho, both integral to their side's defensive solidity, will be assessed after recent absences.
Benjamin Mendy looks likely to miss out, while Leroy Sane's recovery from a knee injury continues in the backdrop.
A debut for Bergwijn?
The only incoming was Dutch winger Steven Bergwijn, a £27million addition from PSV. He's been enjoying a strong 2019/20 campaign, having scored six and assisted 13 in 29 appearances across all competitions.
Mourinho says he'll be involved today in some capacity.
Spurs team news
Moussa Sissoko and Ben Davies remain sidelined.
That means Jan Vertonghen could start on the left side of the defence, with Danny Rose having joined Newcastle on loan this week.
Last time out: Incredible VAR drama
City were twice pegged back, first by Erik Lamela after Raheem Sterling's opener and then by Lucas Moura after Sergio Aguero had struck.
Gabriel Jesus thought he'd bagged the winner in stoppage time, only for VAR to chalk off the goal for a handball by Aymeric Laporte in the build-up.
The rule has proven widely unpopular, but its enforcement left Spurs fans overjoyed that day, just as they had been in the Champions League a few months earlier.
City would certainly take great satisfaction from silencing the Hotspur faithful today.
Tricky run begins for City
Before they have the opportunity to end the Reds' unbeaten streak (assuming it continues) at the beginning of April, they must first navigate trips to Spurs, Leicester, Manchester United and Chelsea.
Oh, and they also face Real Madrid in the last 16 of the Champions League, upon which their season now hinges.
Liverpool's domestic lead could be quite frankly absurd if City continue to stumble.
Three competitions, differing fortunes
Having annihilated Aston Villa in a vintage performance, they were stunned by Crystal Palace in a draw which seemed to all-but confirm Liverpool's triumph.
Then they edged past Sheffield United and thumped Fulham in the FA Cup before tip-toeing through to the League Cup final despite a second home defeat of the season against local rivals Manchester United.
The sense of relentlessness that has characterised Pep's side has faded.
Mourinho chases a big result
In the biggest games, they have failed to deliver. Manchester United, Chelsea, Liverpool and Bayern Munich have all beaten them in the last couple of months.
Can they produce something special today against the champions?
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