Both teams have impressed so far in the league this season, so it should be an interesting contest.
Ahead of the game this weekend, we have looked back on some of the previous meetings between the two sides.
Chelsea 5-2 Leicester 2011/12: Blues thump Foxes
Chelsea secured their place in the FA Cup semi-finals after a comfortable win at home to then Championship side Leicester.
Gary Cahill and Salomon Kalou goals put Chelsea in control of the game after just 20 minutes, with Fernando Torres scoring halfway through the second half to make it 3-0.
Leicester made a late surge as Jermaine Beckford scored just over 10 minutes to go, only for Torres to get his second on 85 minutes.
The visitors scored once again shortly after thanks to Ben Marshall but Raul Meireles sealed the win a goal in added time.
This was the first meeting between the two sides for five years, and Chelsea’s victory sent them on their way to another FA Cup triumph.
Chelsea 3-0 Leicester 2016/17: Chelsea at the treble
The Blues defeated Leicester in the second match of their 13-game winning streak in Antonio Conte’s first season in charge.
Diego Costa gave Chelsea the lead after seven minutes from a corner, with Eden Hazard doubling their lead with just over ten minutes until the break.
Chelsea scored their third in the latter stages of the game as Victor Moses struck past Kasper Schmeichel after a clever assist from Nathaniel Chalobah.
The win spurred Chelsea to continue their winning form, helping them to lift the Premier League trophy later that season.
Leicester 1-2 Chelsea (aet) 2017/18: Extra time needed for Blues
Chelsea faced the Foxes in another FA Cup quarter-final, this time at the King Power Stadium.
Alvaro Morata gave Chelsea the lead shortly before half time after a nice through ball from Willian on the counter attack.
Jamie Vardy then scored with around 15 minutes left to play to send the tie into extra-time.
In the 105th minute, N’Golo Kante sent a cross into the box for Chelsea and Pedro was able to head it over the oncoming Schmeichel, winning the game for the Blues.
Chelsea went on to win the FA Cup that season once again, beating Manchester United 1-0 in the final.