Chris Wilder's side have not picked up the same form prior to the restart but they hope to change their ways as they face Tottenham Hotspur on Thursday.
The Blades are yet to score a goal in the Premier League since football resumed, they have also only taken a single point from a possible nine. United were robbed of the three points at Aston Villa courtesy of a faulty goal-line technology system.
Wilder's side then conceded six goals in their two fixtures against Newcastle United and Manchester United. To dampen the mood even more at Bramall Lane, Arsenal scored an injury-time winner to rule out a trip to Wembley in the FA Cup. The poor run of form has seen the Blades drop four places in the table. They were on course for a potential late bid for the final Champions League spot but now it will be about securing a Europa League place for Wilder.
As for Spurs and Jose Mourinho, their top-four task has toughened as Chelsea and Wolverhampton Wanderers have accumulated maximum points since the restart.
Mourinho was left frustrated when his side gave up a late goal against his former team, Man United, and settled for a draw. Since that opening restart fixture, Spurs comfortably earned themselves three points against West Ham United last week.
Previous meetings
The two sides were forced to share the spoils in a 1-1 back in November. Heung-Min Son put Spurs ahead before VAR ruled out David McGoldrick's equaliser. Fortunately for the Blades, George Baldock rescued a deserved point.
The 1-1 draw also happened to be former manager, Mauricio Pochettino's last game in charge after five years of service for the club. At the time Spurs had just three Premier League wins all season.
Wilder addressed the last meeting in his press conference ahead of the game:
"Quite a lot of things have gone against us this season but it shows the characteristics of this team. At the time, they had just moved into a £600m stadium, some of the best players and Europe.
"That day, I was delighted with performance, apart from waiting 10 minutes to see if John Lundstram’s big toe was offside. I was happy with that as I was on Sunday and if we can take that into Thursday, that would be great," Wilder said.
Team news
After a rough start to football in the summer for the Blades, Wilder received contract boosts this week as Dean Henderson, Richairo Zivkovic and players Phil Jagielka, Jack Rodwell, Kieron Freeman and Leon Clarke all signed extensions which will see them at the club until the end of this season.
John Lundstram, did suffer an arm injury in the FA Cup tie at the weekend and is 'touch and go' for Thursday.
Spurs have no new players added to the injury list and are set to have a full squad ready for the trip up north.
Where to watch
Kickoff is at 18:00 BST and is available for Sky Sports members in the United Kingdom.
Predicted lineups
Sheffield United; Henderson, Basham, Egan, Robinson, Baldock, Berge, Norwood, Fleck, Stevens, McGoldrick, Mousset
Tottenham Hotspur; Lloris, Aurier, Sanchez, Dier, Davies, Sissoko, Lo Celso, Bergwijn, Alli, Son, Kane