A victory for Frank Lampard's side against Palace will lift them above Leicester, so a positive result will be a must on Tuesday night.
Back in 2017, both sides played out a mouth-watering opening day spectacle.
A hectic opening half-hour
After a busy transfer window for both sides, Arsenal welcomed Craig Shakespeare's team on the opening weekend of the Premier League season on a Friday night.
Despite having summer arrival, Harry Maguire, in the starting line-up, Leicester fell a goal behind after 94 seconds when Alexandre Lacazette headed in on his Arsenal debut.
However, two minutes later, Shinji Okazaki equalised for the Foxes after Maguire's header across goal handed the Japanese striker a golden opportunity, which he took. The visitors then took the lead on 29 minutes when Jamie Vardy slid Marc Albrighton's whipped cross in.
Full of twists and turns
Just before the half-time whistle, Danny Welbeck drew Arsenal level to end a half full of entertainment.
Eleven minutes after the restart, Leicester were ahead again when Vardy flicked in Riyad Mahrez's corner past Petr Cech. However, Arsene Wenger introduced Aaron Ramsey and Olivier Giroud to the proceedings, a popular decision.
On 83 minutes, Ramsey smashed the ball past Kasper Schmeichel after beating the offside trap to draw the hosts level for a second time.
Two minutes later, Giroud won the game by holding off Maguire and Wes Morgan to complete the turnaround in front of the Gunners fans.