Coming off the back of a dramatic 3-2 win courtesy of a Bruno Fernandes penalty in the 100th minute, Manchester United face Brighton & Hove Albion for the second time in just four days.
Brighton will doubt be out for revenge and will certainly feel hard done by with Man United winning the last game due to a penalty that was given by VAR after the full-time whistle.
Despite a narrow win and being under pressure for most of the game, Oe Gunnar Solskjaer is expected to make changes.
Here is how his side could look on Wednesday night.
Henderson set for his second start
GK - Dean Henderson
Dean Henderson had little to do when making his United debut against Luton Town in the last round but he dealt with the opposing attack on the few occasions he was called upon.
The highlight of the match came in the form of a jaw-dropping save from the debutant as he got down low to keep out Tom Lockyer's header from close range.
With David De Gea conceding five goals in two games so far this season, Henderson will be called upon for this game as he looks to put pressure on his seasoned colleague and challenge for the number one spot.
RB - Aaron Wan-Bissaka
Having spent the first game of the season on the bench, Aaron Wan-Bissaka has now played 90 minutes in his last two games and although his performance at the weekend was not quite up to his usual standard, it it likely he will start a third game on the bounce as he looks to get back to full fitness.
United fans will certainly be hoping he can quickly get back to the form they have become so accustomed to seeing from the 22-year old.
CB - Eric Bailly
Despite not putting a foot wrong against Luton, Eric Bailly had to settle for cameo role on Saturday's dramatic win.
Many fans felt he deserved to start against Brighton largely due to the below par form of Victor Lindelof who has not been short of criticism the last few months.
Bailly is expected to pick up where he left off in the last round though, and with it looking increasingly unlikely that the club will acquire a new centre-back before the deadline, he can stake a real claim to take Lindelof's place in the team.
CB - Harry Maguire
United's captain has had his critics since his record-breaking £80 million move from Leicester City and along with his centre-back colleagues, he still has a lot to answer for in order to get fans on his side.
However, there is no doubt that he is the club's best central defender and really needs as much game time as possible to rediscover the form that saw such a mammoth fee paid for him.
Thus, Harry Maguire will be at the heart of the defence again as he looks to guide his team to the next round and lay his bad press to rest.
LB - Brandon Williams
There is not much left to say about Brandon Williams that has not already been said. Another academy graduate that is piling serious pressure on a senior player as he did for much of last season.
With question marks still hanging over Luke Shaw, Williams will be given the chance to prove himself in the cup and remind his manager why he kept Shaw out of the team for large periods last term.
CM - Fred
Although Fred was arguably United's best player for the first half of the previous campaign, since he arrival of Fernandes in January, the Brazilian has struggled for game time and it can sometimes be easy to forget that he cost around £53 million.
Now with the signing of Donny van de Beek, Fred faces stiff completion for places and really needs game time in order to prove himself or face a season of warming the bench and picking uo minutes here and there.
CM - Nemanja Matic
There may be an argument for Scott McTominay being given a start in this game, however, Nemanja Matic is the more logical choice.
Whilst McTominay could do with the game time, Matic is the best option to guard the defence and allow Paul Pogba and Fernandes the freedom to get forward week in, week out and with a big game against Tottenham Hotspur this weekend, the Serbian needs to maintain his fitness in this early stage of the season.
Changed forward line likely again
RM - Juan Mata
Juan Mata put in a solid performance last week, opening the scoring in the process and may be giving the chance to repeat his fortunes this week.
Now 32-years old, Mata is more than likely entering the latter stages of his United career and in what could well be his final season at the club, the veteran midfielder could face limited game time in the league.
With that being said, the Spaniard has been a great servant to the club and football in general and deserves no less than a run of games in the cups.
AM - Donny van de Beek
Yet to be handed a Premier League start, Van de Beek has had to settle for a couple of substitute appearances, but was given a start in the last round of the cup.
The new signing will have work to do in order to dislodge the likes of Pogba and Fernandes and will be given the nod in this match with his midfield colleagues expected to be rested for Sunday's game at home to Tottenham.
LM - Jesse Lingard
Jesse Lingard has well and truly fallen down the pecking order in Solskjaer's side and has a mountain to climb if he ever hopes to get back into the first-choice team.
A decent 90 minutes against Luton will have helped his cause and could see him being given another start against Brighton in order to protect Marcus Rashford for the weekend's clash.
ST - Odion Ighalo
When he arrived on loan from Shanghai Shenhua, Odion Ighalo hit the ground running with a goal in every game that he started.
As of late the goals have dried up for the Nigeria International who could do with getting his name on the scoresheet or face depleted minutes.
With that being said, it is thought that he will start this time with Anthony Martial also being saved for the Spurs game.