Manchester United will be hoping to build on their historic victory away to Paris Saint-Germain last week as they welcome RB Leipzig to Old Trafford.
Ole Gunnar Solskjaer’s men will be confident going into the game having maintained an unbeaten run since the international break.
RB Leipzig will arrive in Manchester following their hard fought 2-1 win over Hertha Berlin on Saturday, a result which kept them top of the Bundesliga.
Manchester United are set to be without summer signing Alex Telles as it was revealed he wasn’t part of the provisional squad for the clash.
United will also be without Eric Bailly who remains on the sidelines after picking up an injury on international duty, as well as Jesse Lingard.
Sergio Romero, Phil Jones and Marcos Rojo are all unavailable following their exclusion from the Champions League squad registration.
The visitors will be travelling light after injuries have left the squad running thin. Leipzig are set to be without key first teamers Tyler Adams, Marcel Halstenberg, Lukas Klostermann and Konrad Laimer. They are also unsure on the fitness levels of Nordi Mukiele who would be a big miss for the German outfit.
Manchester United – David De Gea, Aaron Wan-Bissaka, Axel Tuanzebe, Victor Lindelof, Harry Maguire, Luke Shaw, Fred, Scott McTominay, Bruno Fernandes, Marcus Rashford, Anthony Martial
RB Leipzig – Peter Gulacsi, Benjamin Henrichs, Dayot Upamecano, William Orban, Ibrahima Konate, Angelino, Amadou Haidara, Kevin Kampl, Dani Olmo, Christopher Nkuku, Yussuf Poulsen
One to watch
Dayot Upamecano has been at the centre of press speculation for well over a year now, and for good reason. The French centre back has quickly become one of the hottest prospects in Europe after establishing himself as a key player in the Leipzig team.
Upamecano combines pace and power with an ability to read the game which far precedes his young age.
With so much speculation surrounding the youngster's future, what better place to showcase himself to the world than Old Trafford.
Head to Head
Tonight’s fixture will be the first time the teams will have ever met, however, United have won just one of their last four Champions League matches against German opposition (drawing one and losing two)
RB Leipzig, on the other hand, have won both of their previos matches against English teams in European competition without conceding a goal - beating Spurs 4-0 on aggregate in last season's UEFA Champions League last 16.
How to watch
The Game will be available to watch on BT Sport, with the Match kicking off at 8pm GMT