Brighton & Hove Albion entertain Southampton on Monday night at the AMEX Stadium. The Seagulls are in their best form of the season, having lost just once in their last six games while the Saints are flying high in sixth place in the Premier League.
This fixture hasn't been kind to Brighton as the Seagulls have never beaten Southampton in six all-time top-flight matchups. As Graham Potter's men hope seventh time is lucky, here's a look back at their first half-dozen contests.
October 29th, 2017: Brighton 1-1 Southampton: Murray cancels out Davis' opener as spoils are shared
In their match in the top flight since 1983 and their first meeting in almost six years in any league fixture, Southampton went in front through Steven Davis on seven minutes as he reacted quickest to James Ward-Prowse's free-kick, which came off of the angle of the post and bar to head the Saints in front.
Brighton grew into the game and in the 35th minute, Dusan Tadic fired just wide before Anthony Knockaert nearly converted Jose Izquierdo's ball and then dinking one to Shane Duffy, who could only head over.
Brighton came close to equalizing from a Duffy header until Glenn Murray nodded home Pascal Gross' cross in the 52nd minute for his third goal in the last two games. The result saw each side move up one spot in the table as the Seagulls move to 11th while the Saints go up to ninth.
January 31st, 2018: Southampton 1-1 Brighton: Stephens spares the Saints' blushes
Both teams were looking to boost their survival chances with a key win as they faced off at St. Mary's and Brighton had a sight of goal just 27 seconds into the contest as Izquierdo fired over.
In the 14th minute, Solly March was brought down by Wesley Hoedt, who clipped the Seagulls midfielder in the leg. Murray stepped up and fired the penalty past Alex McCarthy, his ninth goal of the season.
Pierre-Emile Hojbjerg nearly equalized as he nodded down Seagulls keeper Mat Ryan's clearance, but he could only hit the crossbar. The Saints were level on 64 minutes after Jack Stephens, who had scored the winner in an FA Cup tie against Watford the previous weekend, back-heeled Ward-Prowse's free-kick past Ryan.
The result extended Southampton's winless run to 12 games, their longest in the top-flight and kept them in the relegation zone in 18th while Brighton moved up one place to 15th.
September 17th, 2018: Southampton 2-2 Brighton: Murray to the rescue again
Meeting on Monday Night Football, Mark Hughes was in charge in this fixture for the first time after the sacking of Claude Puel just six months earlier.
The Saints had the first chance in the 22nd minute as Hojbjerg headed a deep cross that eventually found its way to Danny Ings, who saw his shot blocked. Hojbjerg then went wide after rising to meet a cross from Nathan Redmond.
The hosts opened the scoring with ten minutes left in the first half. Lewis Dunk cleared a cross from Mohamed Eloynoussi, but the ball fell to Hojbjerg, who beat Ryan from 35 yards out to give Southampton a 1-0 lead.
Brighton came out of the traps more aggressive in the second half as Knockaert forced McCarthy into a good save before March went wide with the rebound. In the 64th minute, the Seagulls found themselves down 2-0.
Gaetan Bong took down Ings from behind in the box and he slotted home in the bottom left corner. Brighton responded immediately as an in-swinging free-kick from Knockaert was headed home by Shane Duffy to cut the lead in half.
The visitors kept pushing for an equalizer, McCarthy alert to palm away Jurgen Locadia's effort in the 90th minute, but Ward-Prowse pushed Duffy and Murray coolly dispatched his penalty down the middle, scoring in a third successive league game against Southampton.
March 30th, 2019: Brighton 0-1 Southampton: Hojbjerg strike hands Saints crucial three points
Deep in a relegation battle and on their third manager in this fixture with Ralph Hasenhuttl replacing Hughes, the Saints came to the AMEX just two points clear of the drop. The first half featured little in the way of chances, Stuart Armstrong's half-volley well blocked by Bernardo six minutes before halftime.
Two minutes later, Knockaert sent in a cross that found its way to Murray, but he fizzed his header over the bar. Ings teed up Redmond, who stung his low shot wide as the half came to a close.
It was a moment of magic and some excellent build-up play from Southampton in the 53rd minute that led to the eventual match-winner. Armstrong's lay-off found Redmond and he set up Hojbjerg, who slotted past Ryan.
Brighton had chances to level proceedings, Martin Montoya blasting one off the bar while Davy Propper failed to connect with the net at his mercy. Southampton held firm and their third win in four games, which sent Huddersfield Town down and led to their own eventual survival.
August 24th, 2019: Brighton 0-2 Southampton: Saints seal first win of the season against 10-man Seagulls
Potter had taken over for Chris Hughton at this point following a stuttering finish to the previous season that saw Brighton finish in 15th, but his Seagulls tenure got off to a poor start.
Despite being the better team for much of the opening half, the hosts were reduced to 10 men when Florin Andone was shown a straight red card for a reckless high challenge on Yan Valery. Eight minutes later, Dunk appeared to head Brighton into the lead, only for VAR to rule Dan Burn offsides.
Locadia smashed a shot off the post and the Seagulls' wastefulness would come back to haunt them as substitute Moussa Djenepo curled a right-footed shot past Ryan in the 55th minute and Redmond made sure all three points would go back to St. Mary's after poking home at the back post following Sofiane Boufal's shot across the face of goal.
July 16th, 2020: Southampton 1-1 Brighton: Ings' 20th goal denies Seagulls safety
Coming into the match, Brighton needed just one more victory to assure themselves of a fourth successive season in the Premier League and they looked to be on their way when Neal Maupay took advantage of some poor Southampton defending to put the Seagulls in front after 17 minutes with his 10th goal of the season.
After a double change at halftime by Hasenhuttl, the Saints emerged a different side and Ings' 20-yard curler came inches away from levelling matters, denied only by the inside of the post.
He eventually did find the back of the net in the 66th minute after a perfect pass from Redmond and he slotted home following a slip from Tariq Lamptey to become Southampton's first 20-goal scorer in the top flight since James Beattie in 2003.
Both teams had a sight of winning as Ryan made a fingertip save from Jannik Vestergaard and substitute Yves Bissouma fired wide for the visitors when unmarked from 10 yards. Brighton would secure their Premier League status the following week.