Craven Cottage is the venue for Manchester United's nineteenth league game. Days after battling out in the North West Derby, United will be looking to get back to winning ways after the 0-0 result against Liverpool.
A tail of what-ifs were voiced in regards to United's missed opportunity to get the three points at Anfield - something they certainly hope isn't the case tonight.
Here's what to look out for ahead of the game in West London.
Will Solskjaer make team changes?
United face off against Liverpool once again on Saturday - three days after the Fulham game. Ole Gunnar Solskjaer must therefore choose carefully who he starts and who is rested for the two games. This could mean changes to starting eleven for the inclusion of players such as Mason Greenwood, Donny Van de Beek and Nemanja Matic.
A start for Van de Beek or Greenwood tonight would not be a surprise to many United fans - as the The Reds will have played three games in seven days once their Saturday FA Cup game concludes.
The resting of Bruno Fernandes and Marcus Rashford would be of good use to Solskjaer's side - as they have enough quality squad depth to get a result at Fulham without the need for two of their most involved players this season.
Inflicting damage on Parker's Fulham
United are now unbeaten in the league for a year, having not lost away from home since January 2020, when they lost 2-0 to Jurgen Klopp's Liverpool.
The Reds are now also on the verge of matching Sir Alex Ferguson's 1999 United team run of 17 games unbeaten. This year's United team have managed to go 16 games unbeaten and, could match Sir Alex's side total, as long as they remain unbeaten against Fulham.
Scott Parker's Fulham side have had troubles of their own, failing to score in their last three games at home. United's sensational away form could see them inflict heavy damage on a fragmented Fulham side.
United have won their last four games at Craven Cottage by a aggregate score of 12-1, meaning The Reds could add to that score line with a statement win.
With Manchester City and Leicester City on United's tail, Solskjaer and his side know a win is certainly required. However, if they fail to get a result this could be the game the United boss looks back in regret.