The two sides have already met once this season on December 19th where the sides drew 1-1 at Highbury Stadium.
Wigan have had two of their last three fixtures postponed due to COVID-19 and returned to league football with a 3-3 away draw to Rochdale.
Fleetwood on the other hand, have lost their last three including two league games and an EFL Trophy Cup defeat to Hull City.
After Wigan's recent COVID-19 crisis the majority of the squad is back ready playing and fully fit.
However, centre-back Adam Long is predicted to be out for a few weeks after sustaining an ankle injury away at Rochdale.
Viv Soloman-Otabor, Matthew Palmer and Gavin Massey are all still sidelined, which led to Wigan naming only four substitutes against Rochdale.
For Fleetwood, it's less about injuries and more exits that will change the way the squad may look this weekend. Keeper Joel Coleman remains sidelined whilst loan duo Tom Edwards and Joe Hilton were both recalled by their respective clubs.
There has been a signing for Fleetwood as Janoi Donacien has joined the Cod Army. However, because it was announced this Friday it is unlikely he will feature for this fixture.
Jones, Johnson, Long, Tilt, Pearce, Merrie, Joesph, Gardner, James, Perry, Keane.
Leutwiler, Edwards, Conolly, Mulgrew, Andrew, Finley, Rossiter, Burns, Morris, Camps, Madden.
Ones to watch
For Wigan, there are two attackers that Fleetwood should be worried about. Will Keane and Kyle Joseph are the two strikers that the Latics have been relying on this season. Keane has scored six in 13 whilst Joseph has scored five in 14.
Joseph has promoted through the clubs U23 setup to the first team whilst Keane was signed from Ipswich Town in October for a free transfer.
The Fishermen have one of their stars in the centre of midfield with Callum Camps who has scored 10 and assisted two in his 27 appearances. In the 3-1 loss to Milton Keynes Dons, Camps completed 27 accurate passes and had a pass success rate of 84%, showing his creative side.
In the clubs last six meetings, Wigan have won four, Fleetwood have won one and the sides have shared the spoils once.
The last meeting between these two was this season where the result was 1-1. Danny Andrew's superb strike from 35-yards-out gave Fleetwood the league before an Oliver Crankshaw header equalised for the visitors.
How to watch
The game will be available to UK viewers via IFollow and kicks off at 3pm.