These two sides met earlier on in the season where the Cobblers edged it with a 1-0 win.
Adam Long isn't expected to feature for Fleetwood after picking up an ankle injury against Rochdale whilst keeper Joel Coleman is still sidelined with a long-term injury.
Northampton boss Keith Curle has no fresh injury concerns.
New signing Peter Kioso, who has singed from Luton Town until the end of the season, will not feature after the deal was done after the deadline for players to play.
Leutwiler, Andrew, Mulgrew, Connolly, Edwards, Rossiter, Finley, Burns, Morris, Camps, Madden.
Arnold, Harriman, Bolger, Sowerby, Marshall, Missilou, Watson, Mills, Hoskins, Warburton, Ashley-Seal.
Ones to watch
Striker Paddy Madden got himself an assist in the Fishermen's last game and the 30-year-old has five goals and four assists in 21 league appearances.
Although some may have expected a few more goals this season, Fleetwood's ‘Mr Reliable’ is crucial to the attack and is looking for his 50th goal for the club in what will be his 140th appearance.
Just like their opponents, Northampton's attack hasn't quite been putting up the numbers some would have wanted. However, Sam Hoskins has been a mainstay in the side this season.
His three goals and four assists in 22 league games have been a big part of Northampton going forward.
His career stats, 51 goals and 31 assists in 299 games, show he knows what to do in an attacking phase of play and his presence on the right-hand side is crucial for Curle, who will be hoping his winger gets a winner in his 300th career appearances.
Northampton edged their first meeting this season which comes as a bit of a surprise. Fleetwood have won four of the last six meetings between the two sides, with the Cobblers winning one and one game resulting in a draw.
How to watch
The game will be available to all UK fans via the streaming platform iFollow at a cost of £10 with kick-off time 7:45 pm.