Ralph Hasenhuttl’s men were victorious in the FA Cup fourth round clash between the sides on Saturday and they will now be looking for a repeat result in the Premier League.
Arsenal, on the other hand, will be looking for revenge as they look to climb above the Saints in the table and continue their push for European football next season.
Southampton will be without Kyle Walker-Peters for the visit of Arsenal.
The full-back was arguably the match winner in the Fa Cup tie on Saturday as his cross led to a Gabriel own-goal, the only goal of the game.
He is ruled out with an injured quad, whilst left-back Ryan Bertrand will also be missing through suspension.
In fact, Southampton could well be without nine first-team players due to various ongoing injury concerns.
However, a boost for the Saints will be that Nathan Redmond is fit again and will at least be on the bench against Arsenal.
For Arsenal, captain Pierre-Emerick Aubameyang will once again be unavailable after missing the cup clash for “personal family reasons.”
Mikel Arteta will also be without Kieran Tierney, who has a calf problem.
The last league meeting between the two sides came back in December and might be seen as the turning point in Arsenal’s season.
Sat 15th in the table, they hosted a Saints side who were flying high in 4th place.
After going a goal down early on, courtesy of former player Theo Walcott, the Gunners battled back and earned themselves a point thanks to a Pierre-Emerick Aubameyang equaliser. This was despite playing the last half an hour with 10 men. Since then, they have lost only once in the league and sit just two points behind Southampton going into today’s meeting.
Ones to watch
Always Southampton’s danger man, the clinical striker is back from injury and looking to restart his goal scoring form.
The Englishman has scored seven league goals this season, despite missing five games through injury across the season.
He’s averaging a goal every two games so far this season and will be looking to net against Arsenal having missed out on a goal in the cup clash.
Like Ings has for Southampton, Lacazette has often been Arsenal’s go-to man this season.
With Aubameyang seemingly forgetting how to score, it has been up to Lacazette to fire Arsenal into some sort of goal-scoring form.
Also like Ings, the Frenchman has scored seven league goals this season and will be looking to add to that tally tonight.
It will be hard going however, he will be playing up against the formidable centre-back partnership of Jan Bednarek and Jannik Vestergaard
Arsenal’s upturn in form has gone hand-in-hand with this young man’s inclusion in the side.
The 20-year-old has been excellent in recent weeks, bagging three assists in the last five games.
His team have won four of the five games that he has started this season and he will be looking to prove a point to his manager, with the club in talks to sign playmaker Martin Odegaard from Real Madrid.
How to Watch
The game will be shown live on BT Sport 1 and BT Sport 1 HD from 7:30pm with kick-off at St Mary’s getting underway at 8:15pm.
Live text updates are also available on the VAVEL website and the Southampton VAVEL Twitter Page.