Manchester United and Southampton will meet for the 67th time on Tuesday evening. United were shocked last week when Sheffield United beat The Red Devils 2-1 at Old Trafford.
Ole Gunnar Solskjær's men failed to respond at the weekend with a win when they drew 0-0 with Arsenal.
The Saints last league win came at the beginning of January when they caused an upset and beat Liverpool 1-0. However, Ralph Hasenhüttl's side have won twice in the FA Cup since then, including a 1-0 against Arsenal.
A win for United would take them level on points with rivals Manchester City at least until Wednesday. And for the away side, a win for them would take them level on points with Aston Villa at least until their next game.
For Manchester United Scott McTominay had to come off with stomach cramp and it’s uncertain if that will make him unavailable for the meeting with The Saints. Defenders Victor Lindelof and Eric Bailly are both fit.
Phil Jones remains unavailable as he recovers from a long term injury.
And for Southampton, Ibrahima Diallo, Oriol Romeu and forward Theo Walcott are doubts as they were all substituted with injuries during their game with Aston Villa on Saturday. Nathan Tella is also a doubt for the match.
Jannik Vestergaard and Mohamed Salisu, midfielder Will Smallbone and attacker Michael Obafemi are all unavailable.
Kyle Walker-Peters remains a doubt for Hasenhüttl's side.
Manchester United: De Gea; Wan-Bissaka, Bailly, Maguire, Shaw; Fred, Matic; Pogba, Fernandes, Rashford; Martial
Southampton: McCarthy; Bertrand, Stephens, Bednarek, Valery; Djenepo, Jankewitz, Ward-Prowse, Armstrong; Adams, Ings
Ones to watch
Southampton will have to keep a close eye on Bruno Fernandes as always. The Portuguese midfielder has been pulling the strings ever since his arrival at Old Trafford. Fernandes also scored in the reverse fixture when he started United's impressive 3-2 comeback.
Edinson Cavani could be rested in this game with Anthony Martial coming back into the squad, however the Uruguayan could come off the bench once again to score against The Saints. United's number seven seems to perform best when he comes on as a substitute, can history repeat itself?
Danny Ings is the main danger man for Southampton. The English striker has found the net seven times this season, including the winning goal against Liverpool. Ings will be giving the England manager, Gareth Southgate, a head ache as he is spoiled for options when it comes to strikers.
His English club team mate, James Ward-Prowse is another player that could cause United problems. The midfielder scored a freekick past David De Gea in November and assisted The Saints other goal. Southampton's captain has scored four and assisted five this campaign.
Head to head
United were victorious 3-2 last time these two sides met. Edison Cavani came off the bench and scored twice to turn the game on its head after The Saints took a 2-0 lead into half time. Midfield maestro Bruno Fernandes got the other goal on the day for The Reds.
The last time Southampton won at Old Trafford was in 2016 when Charlie Austin scored an 87th minute winner. Since then they have played ten times. The two sides have drawn half of those games with The Reds winning the remaining five.
How to watch and kick off time
The game is set to kick off at Old Trafford at 20:15 (BST) and will be broadcasted live on TV on BT Sport.
Ole Gunnar Solskjær on the Southampton game and their current injuries: “I expect a similar team that we played against.
"It’s a strong XI - I know they have a lot of injuries, that’s to be expected over the course of the season with the football they play: high intensity, direct, loads of energy.
"They’ve just hit a moment with loads of injuries.
"When you get to that moment, with players coming back and there’s an injury in the squad and you have to come back too early.
"I’ve been lucky in that respect; I have a strong and healthy squad.
"I haven’t had to risk players and I’ve rotated when there have been risks.
"There have been a few times where I’ve had to leave players out.
"We’ve been lucky in that respect, we haven’t had injuries.
"Hopefully they can get theirs fit because this season is relentless.”
Ralph Hasenhüttl on the current injury crisis at Southampton and if this is his most challenging time of his career: "No.
"It is not long ago that we won against Liverpool.
“Things can change quickly in football particularly when you have injuries, which are a massive problem for us at the moment.
"This is definitely tough but on the other side, the good thing is that we have 29 points.
“We had some really strange moments not that long ago, when we were at the bottom end of the table and we were struggling massively.
“That has gone and we are in a better mode, and although we didn’t win the last games.
"We will come back on the winning track, that is for sure.
“We know that we can be competitive against United so let’s go there and do our best. ”