The Clarets, on the other hand, had two impressive wins against Liverpool and Aston Villa before new Chelsea boss Thomas Tuchel grabbed his first home win beating Sean Dyche's men 2-0.
Dyche could be without several first-team regulars for this clash. Charlie Taylor and Ashley Barnes are both touch and go whilst Josh Brownhill is also unlikely to start and will need checking again before kick-off.
Other potential emissions could be striker Chris Wood and winger Robbie Brady who both picked up knocks against Chelsea.
It's unlikely all of the above will miss the game, but if they do it will leave Dyche short of options making this tie even tougher then it already is.
Sergio Aguero could play a part for Man City after coming back from COVID-19 whilst Kevin De Bruyne and Nathan Ake are both injured and will not travel to Turf Moor.
Pope, Lowton, Tarkowski, Mee, Pieters; McNeil, Cork, Westwood, Gudmundsson; Barnes, Rodriguez.
Ederson, Walker, Stones, Dias, Cancelo; Silva, Rodrigo, Gundogan; Marhez, Torres, Sterling.
Ones to watch
It is going to be a tough one for Burnley as they come up against arguably the best side in the league but if youngster Dwight McNeil plays well then they could make it easier for themselves.
The 21-year-old's stats don't make for great reading with only one goal and two assists in his 16 league appearances. However, his 79.8% pass success rate shows that when on the ball and involved he is comfortable.
His goal came in Burnley's last game against Aston Villa and that should hopefully give him the confidence to get on the ball more and create chances for Burnley.
For City there are two players in fine form that Burnley may have trouble facing, the first is John Stones, who has revitalised his career under Pep Guardiola.
He has become a brilliant ball-playing defender that can also match physical presence with someone like Barnes and could make it very difficult for the Clarets strikeforce.
In the attack, Algerian international Riyad Marhez has been deadly this season with five goals and two assists in 11 Premier League appearances. His blistering pace and technical ability could cause problems with Pieters and be crucial for City's attack.
In the last 14 fixtures between the two sides, Burnley have managed only one win against City which came on the 14th March 2015.
However, apart from that result, the two sides have drawn twice with Man City having won 11, giving them a huge advantage going into this game.
How to watch
For all UK viewers, the game is live on BT Sport 1, with kick-off at 18.00 BST. It will also be available on both club TV channels. You can also follow the text commentary on VAVEL.