Aitor Karanka's men are without a win in four league games and have only won one of their last 12 games in all competitions.
Both sides will be looking to pick up three very important points as they both aim to fulfil their target of avoiding relegation.
For the Blues, attacking midfielder Alen Halilovic is doubtful as he is still not match fit after recovering from a groin injury.
Centre-half Marc Roberts is unavailable for selection as he serves the last of his three-game suspension.
Loanee's, Yan Vallery and Rakeem Harper, could be involved from the start.
As for Luton, full-back James Bree looks set to miss this weekend's fixture as he is still recovering from a calf injury.
Irishman Eunan O'Kane is the only other absentee as he is still completing rehab on a broken leg suffered last year.
Glen Rea could replace Luke Berry in midfield for Jones' men but aside from that, it is likely he will stick with a similar starting XI.
Etheridge; Valery, Dean, Friend, Pedersen; Gardener, Sunjic; Sanchez, Harper, Bela; Hogan.
Sluga; Potts, Lockyer, Bradley, Pearson; Mpanzu, Dewsbury-Hall, Rea; Clark, Collins, Cornick.
Karanka tends to set his team up in a 4-2-3-1 formation and Jones is likely to stick his usual 4-3-3 setup on the weekend.
Ones to watch
Birmingham City - Scott Hogan
28-year-old Scott Hogan has maybe not hit the net as much as he would've liked so far this season, but his quality in front of goal is undeniable.
Whilst he has only scored five goals this campaign, last season he bagged ten goals in just 20 starts.
Hogan offers the ability to hold the ball up but also possesses lightning speed which allows him to get in behind opposition defences.
His movement is key to Birmingham's offensive play and he has the presence of mind to pick up some really dangerous attacking positions.
He has a real eye for goal and although this season has not gone entirely to plan so far, if he finds some form, he can be a real handful for opposing defenders.
Luton Town - Kiernan Dewsbury-Hall
The 22-year-old plays in central midfield and has the technical ability to run a game.
His range of passing is excellent and his vision and execution of finding teammates with all types of passes is a joy to watch.
Dewsbury-Hall has started 18 games so far this campaign, scoring two and turning provider for another three.
He has the highest average rating out of the whole Luton squad and his consistency has been refreshing for Hatters fans.
The Englishman has a hidden eye for goal and is known for striking from outside of the box. He attends to his defensive duties when called upon and is an all-round talented player who could certainly make the difference in this weekends affair.
The last three times these two sides have met, Birmingham have won two and there has been one draw.
The last time these two played was in November of last year. The game ended 1-1 with goals from Matthew Pearson and Lukas Jutkiewicz sharing the spoils at Kenilworth Road.
The last time Birmingham beat Luton was in January 2020 when goals from Jutkiewicz and Gary Gardener were enough to see them past the Hatters despite James Collins equalising in the second half.
Last time out:
Where to watch
The game kicks off at 15:00 BST on Saturday 13 February 2021.
For Blues fans, the game can be watched by purchasing a live video match pass which can be found in the BluesTV section of their website.
For Hatters fans, the same process can be followed with the live video match pass being found in the iFollow section of their website.
Both are for a cost of £10.