The Rams' last fixture away at Barnsley was postponed due to a waterlogged pitch at Oakwell.
This time they face stern opposition in Middlesbrough, with Neil Warnock's men currently sitting seventh in the table.
The home side will be having to contend without star man Krystian Bielik once again, with the Polish international ruled out for the rest of the season after sustaining his second ACL injury in just over a year against Bristol City on January 30.
Dael Fry and Marcus Tavernier still remain doubts for the game, with Fry suffering with a minor calf issue that kept him out of last week's 4-1 defeat to Brentford and Tavernier still with a slight knee problem.
Whilst both have done some training, it is unlikely that either will figure against Derby.
January signing Nathaniel Mendez-Laing could be in line to make his Boro debut, but is likely to come off the bench rather than start from the off.
Marshall; Byrne, Clarke, Wisdom, Buchanan; Bird, Shinnie; Roberts, Knight, Jozwiak; Kazim-Richards.
Bettinelli; Fisher, Dijksteel, McNair, Bola; Howson, Morsy; Kebano, Saville, Bolasie; Assombalonga.
Ones to watch
The hosts will look to 34 year-old striker Colin Kazim-Richards to grab their goals against a Boro backline that has been vulnerable in recent weeks.
The former Turkey international has five goals to his name in the league this season, and will be looking to add his tally once more.
In their own backline, Derby will need centre-back Matthew Clarke to be on top form if they are to control the game and stand a chance of taking points to climb up the table with.
Before their previous poor result, Rooney's side had kept three consecutive clean sheets, with former Portsmouth man Clarke playing an integral part in the shutouts.
The boss may hand January signing Patrick Roberts his first start for the club, with the winger looking to impress against the team he spent the first part of this season with, making 10 appearances in the red of Boro.
As for the visitors, they need Congolese forward Britt Assombalonga to step up and show his quality, with the 28 year-old scoring just once in his last seven outings.
January signing Yannick Bolasie will be hoping to kickstart his Boro career into action, after a largely uninspiring first two games.
Warnock may need to call on his bench for some inspiration if things are still in the balance, and Duncan Watmore will hope to provide some added firepower if need be.
This will be the second meeting of the two sides this season, with Boro running out 3-0 winners at the Riverside Stadium in late November. Goals from Marvin Johnson, Assombalonga and Clarke (og) sealed it in the return fixture, so Derby will hope for a better outcome this time.
The Boro have become somewhat of a bogey team for their hosts in recent years, with Derby winning just two of the last 12 games between the teams, with four draws and six Middlesbrough wins in that time.
The Rams did emerge victorious in the last fixture between the two at Pride Park back in 2019 though, and they will hope to continue that trend.
How to watch
Kick off: 15:00 BST, Saturday February 13.
The game will be available for both sets of fans from either club's website, with Derby using their own service RamsTV whilst Boro will be streaming the game on iFollow.
What the managers have said
Whilst speaking to local media, Rooney was quietly confident about his side's chances and complimentary of his opposing manager. He said:
"He is an experienced manager and he knows how to get the best out of his players. Saturday will be no different, it will be a difficult game for us, we know that.
"We have to make sure we do our job. If we do our job in terms of preparation, then we will be OK."
In the other dugout, Warnock had some choice words about the refereeing of recent games. He said:
"Every week is a challenge for me. I look at who is refereeing here, rather than who is their manager.
"Especially nowadays, it seems to be half the battle!"
He also gave an update on his squads injury troubles, and said:
"You do feel a little bit down at times as a manager sometimes when your so-called best players are out injured. It never seems to be your fringe players.
"But whatever injuries, we've just got to get on with it really."