City are now winless in their last five games after their 2-0 defeat to Norwich City during the week.
Teemu Pukki put the Canaries 1-0 up in the first half after Emiliano Buendía played a blinding ball, through the Coventry defence, into the striker's feet.
On the stroke of halftime, the roles reversed as Buendia added to his assist with a tap-in past Ben Wilson. Pukki intercepted the ball off Kyle McFadzen, on the halfway line, and drove towards the goal before playing the ball across the face of goal for Buendia to double Norwich's lead.
The Bees lost 2-1 to Queen's Park Rangers on Wednesday night. Brentford have now failed to win their last two games as Norwich push further ahead in the title race.
In the second half, QPR scored twice in the space of four minutes.
Sam Field celebrated his debut by drilling the ball into the bottom corner to level the scoring.
Charlie Austin put the R's ahead minutes later. Lee Wallace dragged the ball back, across the penalty box, for the loanee to smash the ball into the back of the net.
Coventry will be without Fankaty Dabo, Matt Godden and Jodi Jones once again as the three players remain on the sidelines.
The Bee's will be without Shandon Baptiste once again as he recovers from knee surgery.
Coventry City: Wilson; Rose, McFadzean, Hyam; Costa, Allen, James, Shipley; O'Hare, Hamer; Walker.
Brentford: Raya; Dalsgaard, Reid, Bech, Henry; Janelt, Jensen, Dasilva; Fosu, Toney, Canos.
Ones to watch
Coventry - Gustavo Hamer
The Brazilian joined City in the Summer and is one of their most vital players.
The midfielder has five goals so far and will look to expose Brentford through the middle as the Blues hope to win their first game in February.
Brentford - Ivan Toney
Undoubtedly, the Bees' standout player is Toney. The striker has 24 goals to his name in 30 appearances alongside nine assists!
The Englishmen scored a brace against City in the reverse fixture when Brentford won 2-0.
Brentford 2-0 Coventry City (17/10/2020)
Where to watch
UK residents will be able to watch the game live on Sky Sports on Saturday, 20th February from 12:00 PM with the game kicking off at 12:30 PM.