Manchester City will look to extend their record-breaking run when they head to London to take on Arsenal.
The fixture marks the continuation of a busy schedule for both sides, with Manchester City running out 3-1 victors at Goodison Park on Wednesday night, whilst Arsenal grabbed a vital away goal in a frustrating 1-1 draw with Benfica in the Europa League.
The Gunners will be hoping to close the gap on the European places with their first league win over the Citizens since 2015.
Mikel Arteta has a near full-strength squad to choose from ahead of Sunday's meeting, although they will be without influential midfielder Thomas Partey.
Meanwhile, Manchester City will be without summer signing Nathan Ake, although the defender is back in training for Pep's side, albeit alone.
The Dutchman is the only confirmed absentee for the visitors, with Ilkay Gundogan set to undergo a late fitness test having missed Wednesday's victory over Everton with a muscle injury.
Ones to Watch
Pierre Emerick-Aubameyang will be one to watch for the Gunners having recently rediscovered his scoring form.
The Gabon international grabbed a quickfire hat-trick in last weekend's 4-2 win over Leeds United and is known for causing many problems for Pep Guardiola's side in the past.
Auba scored both goals in his sides 2-0 win over City in last season's FA Cup semi-final and will be hoping to get in behind the opposition's trademark high line again tomorrow.
Bernardo Silva ran the City midfield in the win over Everton and grabbed himself a late goal as City made it 17 wins in a row.
With one eye on Wednesday's Champions League clash with Borussia Monchengladbach, Pep may opt against risking Gundogan in fear of rushing the German back too soon.
Bernardo has been the man in recent weeks, expect another big showing from him tomorrow.
Arsenal: Leno; Bellerin, Holding, Gabriel, Tierney; Elneny, Xhaka, Odegaard; Pepe; Aubameyang; Martinelli
City: Ederson; Cancelo, Stones, Dias, Zinchenko; Rodri, Bernardo, Foden; Mahrez, De Bruyne, Jesus.
How to Watch
This Premier League clash between Arsenal and Manchester City will kick-off at 4:30pm GMT on Sunday, February 21.
The game will be shown live on Sky Sports Main Event and Sky Sports Premier League.