The Seagulls come into this clash on the back of consecutive league draws against Burnley and Aston Villa with a fifth round FA Cup defeat to title contenders Leicester City in between, just four points above the bottom three.
The Eagles have lost back-to-back Premier League contests against Leeds United and Burnley, both shutouts and sit just seven points above the relegation zone.
Team news - Brighton & Hove Albion
Florin Andone is close to re-joining the squad where he will continue the rehabilitation process of his knee injury.
Tariq Lamptey continues to recover from a thigh injury suffered in mid-December.
Solly March is also in rehab after undergoing a knee operation with no date set for his return.
Adam Webster is unlikely to feature as the club are still assessing any possible ligament damage to his ankle and foot.
Team news - Crystal Palace
James McCarthy is back in training with manager Roy Hodgson keeping an eye out on the midfielder before determining his status.
Wilfred Zaha will miss out as he recovers from a thigh issue, the forward himself saying it feels better, but needs work in the gym.
On October 18th, 2020, Brighton salvaged all three points thanks to a late equalizer by Alexis Mac Allister despite going down to ten men in stoppage time.
Zaha gave Palace a 19th-minute lead from the penalty spot after Lamptey fouled Michy Batshuayi in the box despite replays showing there was little contact.
It looked like the Eagles were on course for all three points until substitute Aaron Connolly played a lay-off to fellow sub Mac Allister, who scored from the edge of the area.
The Seagulls were reduced to ten men after Lewis Dunk was trying to pounce on a loose ball, but he caught Gary Cahill studs up with a challenge and was dismissed.
Palace stayed 12th in the table while Brighton remained 16th.
Ones to watch
Dunk is joint-second on Brighton's scoring charts, having found the back of the net three times, but his threat in the air, particularly set pieces make him a danger man.
With Zaha sidelined, the Palace attack is significantly weakened as Eberechi Eze and Christian Benteke are second with three goals apiece, the latter making his first start in an Eagles shirt recently.
Brighton & Hove Albion: Sanchez; White, Dunk, Webster; Veltman, Gross, Bissouma, Burn; Mac Allister, Trossard; Maupay (3-4-2-1)
Crystal Palace: Guaita; Mitchell, Cahill, Kouyate, Clyne; Eze, Riedewald, Milivojevic, Townsend; Mateta, Benteke (4-4-2)
The match will be shown on Sky Sports Premier League. Subscribers can also stream the cotest on the Sky Sports website and SkyGo app with kickoff at 15:00 GMT.