Despite the Spurs' poor recent run of league results, a win against Palace will be three league wins in a row for Jose Mourinho’s men.
Compared to their opponents, with Roy Hodgson's side looking to build on their last three and go four games unbeaten.
Ahead of the game, VAVEL UK look back at the five previous meetings between the two teams in the league.
Crystal Palace 0-1 Tottenham Hotspur - November 10th 2018
In this tie, the visitors won from a second half goal from Argentine defender, Juan Foyth.
Palace striker, Alexander Sorloth, had a fantastic opportunity at the death to grab an equaliser, but he drilled his effort directly at Hugo Lloris.
This result meant the hosts had gone six home games without a win for the first time since 1997/98, whilst the visitors built on their away form and had won more away games than anyone else in the league during 2018 (12.)
Spurs won seven games in a row in the league against Palace after this victory.
Tottenham Hotspur 2-0 Crystal Palace - April 3rd 2019
In a joyous occasion, this fixture marked the grand opening of the Tottenham Hotspur Stadium.
After playing their home games at Wembley Stadium for over a year, the hosts aimed to open their new stadium with a bang in front of 59,215 fans.
Two second half goals from Heung Min-son and Christian Eriksen saw The Lilywhites take all three points.
Son scored in the 55th minute and marked history becoming the first player to score in the stadium with a left-footed shot from the edge of the area, before Eriksen scored from six yards out.
Tottenham Hotspur 4-0 Crystal Palace - September 14th 2019
In the most recent league game held in North London, this weekend's hosts beat Palace with four goals scored in the first half.
Son scored a brace with a Patrick van Aanholt own goal in between before Érik Lamela finished the scoring for the afternoon.
Spurs equalled their biggest-ever win against Palace in all competitions with this result, having only beating their opponents by such margin in 1987 in the FA Cup.
Crystal Palace 1-1 Tottenham Hotspur - July 26th 2020
In the last game of the long, drawn out season because the Covid-19 pandemic, Palace hosted Spurs.
Spurs opened the scoring after a goal in the 13th minute from Harry Kane, with Jeffrey Schlupp scoring the equaliser in the 53rd minute.
With the victory, the visitors gained just enough points to qualify for the UEFA Europa League for the following season.
Palace were the better of the two sides, but neither side managed to find enough quality to finish the game with a win.
Crystal Palace 1-1 Tottenham Hotspur - December 13th 2020
In one of the few games that hosted fans towards the end of 2020, the London derby ended in a draw.
In an almost carbon copy of the fixture prior to this game, Kane opened the scoring before Schlupp scored an equaliser in the second half.
Despite the game ending in a draw, Spurs became unbeaten in their last nine league games.
The London teams have played 23 games head-to-head, with Spurs winning 13 games and Palace winning three.
Spurs will need to win the game as they look to press on for a top four position come the end of the season, with Palace in the middle of the table avoiding a relegation battle.