The visitors come into the game on the back of a 1-1 draw away to Blackburn Rovers on Tuesday evening but could go second with a win at Luton providing other results go their way.
The Hatters come into the game after a 3-0 defeat at the hands of Norwich City last weekend, and will be looking to bounce back when the two sides meet on Saturday.
Swans manager Steve Cooper will be without Jordan Morris, Tivonge Rushesha, Liam Cullen and Steven Benda as they all are all still recovering from their injury problems.
Luton Town (4-4-1-1)
Sluga, Cranie, Pearson, Naismith, Potts, Ince, Tunnicliffe, Dewsbury-Hall, Moncur, Berry, Adebayo.
Swansea City (3-4-3)
Woodman, Naughton, Cabango, Guehi, Roberts, Fulton, Grimes, Bidwell, Hourihane, Lowe, Ayew.
Ones to watch
Elijah Adebayo signed for Luton on Transfer deadline day from Walsall for an undisclosed fee. Since signing for the Hatters he has scored two goals and contributed with one assist in his six Championship appearances.
Andre Ayew has been in fine form for Swansea recently and has scored 14 goals in 33 appearances this season. In his last four appearances he has scored five goals for the Swans.
The last time these two sides met it was Swansea who triumphed as they ran out 2-0 winners back in December. In the last five meetings Swansea have the upper hand winning four and Luton winning one.
How to watch
Due to the current national lockdown, there will be no fans in attendance when the two sides meet at Kenilworth Road on Saturday. This means the game will be available on iFollow through Luton and Swansea's respective websites, with passes priced at £10.
The game kicks off at 15:00 GMT on Saturday 13 March 2021.