Curle will celebrate his one week anniversary in replacing the outgoing Harry Kewell on Tuesday, but is yet to achieve his first three points after a draw with Port Vale and an unlucky defeat at the hands of Cambridge United.
Oldham have just one win in their last eight, and have slipped to 17th in the table.
Their hosts, Scunthorpe, are in 18th and have one win in their last six, but were unlucky not to defeat Leyton Orient on Saturday.
The Iron have a number of injury difficulties, with Harrison McGahey and George Taft both missing.
George Hornshaw, Aaron Jarvis, Adam Kelsey and Olufela Olomola are all also absent for Tuesday.
Meanwhile with the Latics, attacking trio of George Blackwood, Marcus Barnes and Zak Dearnley will be out for an extended period of time.
Cameron Borthwick-Jackson and Harry Clarke are both injured, but Kyle Jameson has completed his suspension and is back for contention.
Scunthorpe United: Howard; Rowe, Clarke, Bedeau, Brown, Beestin, Karacan, Gilliead, Hallam, Van Veen, Loft.
Oldham Athletic: Walker; Diarra, Piergianni, Badan, Adams, McCalmont, Ntambwe, Fage, Hilssner, Keillor-Dunn, McAleny.
Ones to watch
Having just returned from injury, Loft is fighting for sharpness, and Oldham may have to hope he has an off day.
Loft is one of the most underrated frontmen in the division, with eight goals and six assists and an injury hindering that, he can be a force to be reckoned with.
The former Wrexham winger showed in his last match what he’s truly capable of.
Keillor-Dunn has got off to a flying start under Curle, with two goals last game, and will look to carry that into the Scunthorpe match. With eight goals from the wing this campaign, Keillor-Dunn must be utilised by Curle in order to see out games.
The last time these two sides locked horns was in November, which saw Scunthorpe steal the bragging rights. Goals from Kevin Van Veen and Jacob Bedeau saw the scoreline result in a 2-0 victory to the Iron.
The match is available on iFollow via Scunthorpe or Oldham’s respective club websites, with match passes at £10 for those in the United Kingdom.