The Chairboys are now 12 points from safety with another defeat on Saturday all but confirming their doom.
Most recently, City lost away to Luton Town during the week in a tough defeat.
James Bree opened the scoring in the 23rd minute with a volley at just inside the area which Ben Wilson could not keep out.
During the week, Wycombe also lost by two goals when they hosted promotion chasers, Barnsley.
On the stroke of half-time, Cauley Woodrow scored the first of the match with a penalty past David Stockdale.
Daryl Dike then scored a goal at the beginning and the end of the second half, either side of Alex Mowatt's red card, to secure the three points for the visitors.
Coventry will be without Jodi Jones once again as he carries an ACL injury.
McFadzean is out for the clash as the defender faces suspension despite City appealing the red card.
Carrying a muscle injury, Jordan Obita is out until the end of the month for Wycombe.
Coventry City: Wilson; Ostigard, Rose, Hyam; Da Costa, Hamer, Kelly, James, McCallum; O'Hare; Biamou.
Wycombe Wanderers: Stockdale; Grimmer, Stewart, Tafazolli, Obita; Wheeler, Knight, Mehmeti; McCleary, Ikpeazu, Onyedinma.
Ones to watch
Coventry - Callum O'Hare
The 22-year-old is one of the more creative players in the City side with five assists, the most in the team, alongside two goals.
Usually staring in the central role, his skilfulness and agility will cause the Wanderers defence a lot of trouble on Saturday.
Wycombe Wanderers - Joe Jacobson
The 34-year-old has made 29 appearances so far this season and is the Chairboys’ third top goalscorer, however he is the player with the most goal involvements in the side.
Having the ability to score and assist, Jacobson will look to break down Coventry's defence.
Wycombe Wanderers 1-2 Coventry City (12/12/2020)
Where to watch
UK residents will be able to watch the game live on the clubs' respective iFollow pages on Saturday 20th March, with the game kicking off at 3pm.