Most recently, West Ham narrowly lost away to Manchester United last Sunday night, as a very defensive-minded team could not create enough chances to get a goal at Old Trafford.
In the 53rd minute, Bruno Fernandes whipped a great ball towards the front post from the corner. Scott McTominay rose high, putting off Craig Dawson who saw the ball bounce in off his head.
On the other hand, Arsenal won their most recent game against fierce rivals, Tottenham Hotspur at the Emirates Stadium.
Erik Lamela opened the scoring in the 33rd minute, just 14 minutes after replacing Heung-Min Son who hobbled off the pitch. The Argentine showed great composure, scoring with the 'rabona' technique.
However, Martin Ødegaard equalised on the stroke of halftime with the ball deflecting off Toby Alderweireld as it rolled past Hugo Lloris.
Halfway through the first half, Alexandre Lacazette was brought down inside the penalty area by Davinson Sanchez despite the striker already taking his shot before contact was made.
The Frenchman then put the ball on the penalty spot before cooly slotting it past to make it 2-1 and closing the gap between the Gunners and the Spurs in the table.
Arthur Masuaku will be missed again as he recovers from a successful knee operation.
Darren Randolph is also nursing an injury alongside Ryan Fredericks, who is also a doubt with a groin strain.
Young winger, Bukayo Saka, is set to miss out with a hamstring injury.
Willian is also likely to miss the London derby with a calf injury.
West Ham United: Fabianski; Coufal, Diop, Dawson, Cresswell, Johnson; Soucek, Rice; Bowen, Lingard, Benrahma.
Arsenal: Leno, Soares, Luiz, Gabriel, Tierney; Partey, Xhaka; Pepe, Odegaard, Smith-Rowe; Lacazette.
Ones to watch
West Ham United - Jesse Lingard
The midfielder has been recalled to the England squad for the first time in two years after his explosive start to life at West Ham. The attacking midfielder is at the centre of the Hammers' attack. Driving West Ham forward superbly, Lingard will look to build on his very impressive start to his new club.
The 28-year old was brilliant in all of his games so far for the East London side, being the standout player on the pitch. Settling in very quickly, Lingard has four goals and two assists in six games, pushing the Hammers towards the Champions League places.
Arsenal - Emile Smith-Rowe
The Englishmen has been a fan favourite amongst Arsenal fans this season for his brilliant performances for the Gunners.
The 20-year-old has assisted four times in 13 appearances so far this season and will look to build on that when he travels to the London Stadium.
Arsenal 2-1 West Ham United (11/12/2020)
Where to watch
UK residents will be able to watch the game live on Sky Sports on Sunday, 21st March from 14:30 PM with the game kicking off at 15:00 PM.